Table 1. Analysis of whole blood and... | American Society of Hematology

Table 1.

Analysis of whole blood and platelet receptor levels in EXOC3 KO mice

Parameter	WT		KO		N	P
Parameter	Mean	SD	Mean	SD	N	P
WBC, ×10³/μL	6.34	1.37	7.569	2.88	13	.19
RBC, ×10⁶/μL	9.63	1.21	10.42	1.81	13	.49
Plt, ×10³/μL	827	155	735	160	13	.09
MPV, µm³	5.27	0.23	5.71	0.21	13	.001
PCT, %	0.34	0.08	0.33	0.06	13	.42
CD41, MFI	6904	1645	7012	1428	13	.67
CD42b, MFI	4194	1352	5049	1266	13	.001
GPVI, MFI	734	186	628	127	13	.002
CD49b, MFI	589	107	639	104	13	.01

Parameter	WT		KO		N	P
Parameter	Mean	SD	Mean	SD	N	P
WBC, ×10³/μL	6.34	1.37	7.569	2.88	13	.19
RBC, ×10⁶/μL	9.63	1.21	10.42	1.81	13	.49
Plt, ×10³/μL	827	155	735	160	13	.09
MPV, µm³	5.27	0.23	5.71	0.21	13	.001
PCT, %	0.34	0.08	0.33	0.06	13	.42
CD41, MFI	6904	1645	7012	1428	13	.67
CD42b, MFI	4194	1352	5049	1266	13	.001
GPVI, MFI	734	186	628	127	13	.002
CD49b, MFI	589	107	639	104	13	.01

Whole blood from WT and EXOC3 KO mice was analyzed on a Pentra ES 60 hematologic analyzer (Horiba), with cell counts corrected for citrate dilution. Washed platelets (2 × 10⁷/mL) from WT and EXOC3 KO platelets were analyzed for surface expression of CD41 (GPIIb), CD42b (GPIbα), GPVI, and CD49b (GPIa) by using flow cytometry. Median fluorescent intensity (MFI) values are reported. Data are presented as the mean ± standard deviation (SD). n = 13. An unpaired, 2-tailed Student t test was used to determine P values, with statistically significant differences in bold.

MPV, mean platelet volume; PCT, plateletcrit; Plt, platelet; RBC, red blood cell; WBC, white blood cell.

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