Maximum abnormalities of coagulation parameters and platelets within 48 hours of lowest fibrinogen level by CRS grade
| . | Patients, n . | Mean (SD) . | Median . | Min-max . |
|---|---|---|---|---|
| Grade 1-2 CRS | ||||
| Platelet, ×109/L | 44 | 83.2 (69.4) | 67.5 | 5.0-276.0 |
| WBC, ×109/L | 44 | 1.2 (1.2) | 0.7 | 0-4.2 |
| aPTT, s | 42 | 37.3 (12.8) | 34.3 | 25.0-100.4 |
| PT, s | 32 | 14.1 (1.7) | 14.1 | 10.1-20.0 |
| INR | 27 | 1.1 (0.2) | 1.1 | 0.9-1.7 |
| Grade 3 CRS | ||||
| Platelet, ×109/L | 24 | 34.9 (29.5) | 25.5 | 9.0-146.0 |
| WBC, ×109/L | 22 | 0.6 (0.8) | 0.2 | 0-2.7 |
| aPTT, s | 23 | 42.4 (9.9) | 40.8 | 27.1-66.4 |
| PT, s | 17 | 14.8 (3.5) | 14.3 | 10.8-26.5 |
| INR | 16 | 1.3 (0.4) | 1.2 | 1.0-2.5 |
| Grade 4 CRS | ||||
| Platelet, ×109/L | 30 | 36.5 (26.5) | 27.5 | 5.0-114.0 |
| WBC, ×109/L | 30 | 0.5 (1.1) | 0.2 | 0-4.7 |
| aPTT, s | 26 | 63.0 (36.6) | 49.4 | 31.3-200.0 |
| PT, s | 13 | 19.2 (9.3) | 18.5 | 10.8-47.1 |
| INR | 19 | 1.6 (0.5) | 1.5 | 1.0-3.0 |
| . | Patients, n . | Mean (SD) . | Median . | Min-max . |
|---|---|---|---|---|
| Grade 1-2 CRS | ||||
| Platelet, ×109/L | 44 | 83.2 (69.4) | 67.5 | 5.0-276.0 |
| WBC, ×109/L | 44 | 1.2 (1.2) | 0.7 | 0-4.2 |
| aPTT, s | 42 | 37.3 (12.8) | 34.3 | 25.0-100.4 |
| PT, s | 32 | 14.1 (1.7) | 14.1 | 10.1-20.0 |
| INR | 27 | 1.1 (0.2) | 1.1 | 0.9-1.7 |
| Grade 3 CRS | ||||
| Platelet, ×109/L | 24 | 34.9 (29.5) | 25.5 | 9.0-146.0 |
| WBC, ×109/L | 22 | 0.6 (0.8) | 0.2 | 0-2.7 |
| aPTT, s | 23 | 42.4 (9.9) | 40.8 | 27.1-66.4 |
| PT, s | 17 | 14.8 (3.5) | 14.3 | 10.8-26.5 |
| INR | 16 | 1.3 (0.4) | 1.2 | 1.0-2.5 |
| Grade 4 CRS | ||||
| Platelet, ×109/L | 30 | 36.5 (26.5) | 27.5 | 5.0-114.0 |
| WBC, ×109/L | 30 | 0.5 (1.1) | 0.2 | 0-4.7 |
| aPTT, s | 26 | 63.0 (36.6) | 49.4 | 31.3-200.0 |
| PT, s | 13 | 19.2 (9.3) | 18.5 | 10.8-47.1 |
| INR | 19 | 1.6 (0.5) | 1.5 | 1.0-3.0 |
Median reference ranges across 2 age groups (6-10 y and 11-17 y) and 2 reagents: aPTT = 31.0-32.8 s; PT = 11.7-11.8 s; INR = 1.04.17