Table 4.

Summary of the estimated effect sizes in different HRQOL domains following HSCT

Author, yDomainEffect size, d95% confidence interval
Sickle cell disease    
 PedsQL    
  Bhatia et al,55  2015 Physical 0.97 (0.22-1.71)* 
Social 0.77 (0.04-1.48)* 
Emotional 1.02 (0.28-1.76)* 
Psychosocial 1.01 (0.27-1.75)* 
Overall 1.10 (0.34-1.84)* 
Thalassemia    
 PedsQL    
  Caocci et al,44  2011 Physical 0.86 (0.31-1.4)* 
Social 1.06 (0.5-1.62)* 
Emotional 0.27 (-0.25 to 0.8) 
Psychosocial 1.25 (0.67-1.82)* 
Overall 2.05 (1.39-2.69)* 
  Cheuk et al,47  2008 Physical 0.41 (-0.24 to 1.05) 
Social 0.16 (-0.49 to 0.8) 
Emotional 0.33 (-0.32 to 0.97) 
Psychosocial 0.17 (-0.48 to 0.81) 
School −0.08 (-0.72 to 0.56) 
Overall 0.21 (0.22-0.18)* 
  Patel et al,51  2018 Physical 0.78 (0.32-1.23)* 
Social 0.26 (-0.18 to 0.7) 
Emotional 0.72 (0.26-1.17)* 
Psychosocial 0.80 (0.34-1.26)* 
School 0.86 (0.4-1.31)* 
Overall 0.69 (0.24-1.14)* 
  Uygun et al,52  2012 Physical 1.07 (0.56-1.57)* 
Social 0.53 (0.05-1.01)* 
Emotional 0.78 (0.29-1.26)* 
School 0.63 (0.15-1.11)* 
Psychosocial 0.55 (0.07-1.02)* 
Overall 0.71 (0.23-1.19)* 
 SF-36    
  Caocci et al,46  2016 (Thalassemia control) Physical Component Score 0.82 (0.48-1.16)* 
Mental Component Score 0.57 (0.23-0.9)* 
  Caocci et al,46  2016 (Sibling control) Physical Component Score −0.27 (-0.6 to 0.06) 
Mental Component Score 0.40 (0.06-0.73)* 
  Javanbakht et al,48  2015 Physical 0.50 (0.16-0.84)* 
Role Physical 0.52 (0.18-0.86)* 
Bodily Pain −0.02 (-0.35 to 0.32) 
General Health 0.19 (-0.14 to 0.53) 
Vitality 0.22 (-0.11 to 0.56) 
Social Functioning 0.33 (-0.01 to 0.66) 
Role Emotional 0.57 (0.23-0.91)* 
Mental Health 0.26 (-0.08 to 0.6) 
La Nasa et al,50  2013 (Transfusion control) Physical 0.17 (-0.09 to 0.43) 
Role Physical 0.88 (0.61-1.15)* 
Bodily Pain 0.82 (0.56-1.09)* 
General Health 0.20 (-0.06 to 0.46) 
Vitality 0.28 (0.02-0.54)* 
Social Functioning −0.04 (-0.3 to 0.21) 
Role Emotional 0.63 (0.37-0.9)* 
Mental Health 0.18 (-0.08 to 0.43) 
  La Nasa et al,50  2013 (Matched general population control) Physical 0.05 (-0.22 to 0.31) 
Role Physical 0.29 (0.02-0.55)* 
Bodily Pain 0.23 (-0.04 to 0.49) 
General Health −0.11 (-0.37 to 0.16) 
Vitality 0.13 (-0.14 to 0.4) 
Social Functioning 0.20 (-0.07 to 0.47) 
Role Emotional 0.39 (0.12-0.65)* 
Mental health 0.41 (0.14-0.68)* 
 WHOQoL-BREF    
  Cheuk et al,47  2008 Physical 0.79 (0.21-1.35)* 
Global 0.26 (-0.3 to 0.82) 
Cultural adjusted 0.22 (-0.34 to 0.78) 
Social Relationships 0.36 (-0.2 to 0.92) 
Environment 0.06 (-0.5 to 0.61) 
  Uygun et al,52  2012 Physical 0.91 (-0.01 to 1.81) 
Psychological 0.22 (-0.65 to 1.09) 
Social Relationships 1.24 (0.27-2.17)* 
Environment 0.34 (-0.53 to 1.21) 
Author, yDomainEffect size, d95% confidence interval
Sickle cell disease    
 PedsQL    
  Bhatia et al,55  2015 Physical 0.97 (0.22-1.71)* 
Social 0.77 (0.04-1.48)* 
Emotional 1.02 (0.28-1.76)* 
Psychosocial 1.01 (0.27-1.75)* 
Overall 1.10 (0.34-1.84)* 
Thalassemia    
 PedsQL    
  Caocci et al,44  2011 Physical 0.86 (0.31-1.4)* 
Social 1.06 (0.5-1.62)* 
Emotional 0.27 (-0.25 to 0.8) 
Psychosocial 1.25 (0.67-1.82)* 
Overall 2.05 (1.39-2.69)* 
  Cheuk et al,47  2008 Physical 0.41 (-0.24 to 1.05) 
Social 0.16 (-0.49 to 0.8) 
Emotional 0.33 (-0.32 to 0.97) 
Psychosocial 0.17 (-0.48 to 0.81) 
School −0.08 (-0.72 to 0.56) 
Overall 0.21 (0.22-0.18)* 
  Patel et al,51  2018 Physical 0.78 (0.32-1.23)* 
Social 0.26 (-0.18 to 0.7) 
Emotional 0.72 (0.26-1.17)* 
Psychosocial 0.80 (0.34-1.26)* 
School 0.86 (0.4-1.31)* 
Overall 0.69 (0.24-1.14)* 
  Uygun et al,52  2012 Physical 1.07 (0.56-1.57)* 
Social 0.53 (0.05-1.01)* 
Emotional 0.78 (0.29-1.26)* 
School 0.63 (0.15-1.11)* 
Psychosocial 0.55 (0.07-1.02)* 
Overall 0.71 (0.23-1.19)* 
 SF-36    
  Caocci et al,46  2016 (Thalassemia control) Physical Component Score 0.82 (0.48-1.16)* 
Mental Component Score 0.57 (0.23-0.9)* 
  Caocci et al,46  2016 (Sibling control) Physical Component Score −0.27 (-0.6 to 0.06) 
Mental Component Score 0.40 (0.06-0.73)* 
  Javanbakht et al,48  2015 Physical 0.50 (0.16-0.84)* 
Role Physical 0.52 (0.18-0.86)* 
Bodily Pain −0.02 (-0.35 to 0.32) 
General Health 0.19 (-0.14 to 0.53) 
Vitality 0.22 (-0.11 to 0.56) 
Social Functioning 0.33 (-0.01 to 0.66) 
Role Emotional 0.57 (0.23-0.91)* 
Mental Health 0.26 (-0.08 to 0.6) 
La Nasa et al,50  2013 (Transfusion control) Physical 0.17 (-0.09 to 0.43) 
Role Physical 0.88 (0.61-1.15)* 
Bodily Pain 0.82 (0.56-1.09)* 
General Health 0.20 (-0.06 to 0.46) 
Vitality 0.28 (0.02-0.54)* 
Social Functioning −0.04 (-0.3 to 0.21) 
Role Emotional 0.63 (0.37-0.9)* 
Mental Health 0.18 (-0.08 to 0.43) 
  La Nasa et al,50  2013 (Matched general population control) Physical 0.05 (-0.22 to 0.31) 
Role Physical 0.29 (0.02-0.55)* 
Bodily Pain 0.23 (-0.04 to 0.49) 
General Health −0.11 (-0.37 to 0.16) 
Vitality 0.13 (-0.14 to 0.4) 
Social Functioning 0.20 (-0.07 to 0.47) 
Role Emotional 0.39 (0.12-0.65)* 
Mental health 0.41 (0.14-0.68)* 
 WHOQoL-BREF    
  Cheuk et al,47  2008 Physical 0.79 (0.21-1.35)* 
Global 0.26 (-0.3 to 0.82) 
Cultural adjusted 0.22 (-0.34 to 0.78) 
Social Relationships 0.36 (-0.2 to 0.92) 
Environment 0.06 (-0.5 to 0.61) 
  Uygun et al,52  2012 Physical 0.91 (-0.01 to 1.81) 
Psychological 0.22 (-0.65 to 1.09) 
Social Relationships 1.24 (0.27-2.17)* 
Environment 0.34 (-0.53 to 1.21) 
*

Indicates an effect size with statistically significant improvement in a quality-of-life domain following hematopoietic stem cell transplant (<0.05).

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