Relationship between PB and BMA flow cytometry
| . | PBpos . | PBneg . | Sn/Sp (%) . |
|---|---|---|---|
| All sample pairs (N = 724) | |||
| BMApos | 327 | 28 | Sn: 92 |
| BMAneg | 10 | 359 | Sp: 97 |
| PPV: 97% | NPV: 93% | ||
| First pair for each patient (N = 477) | |||
| BMApos | 242 | 21 | Sn: 92 |
| BMAneg | 6 | 208 | Sp: 97 |
| PPV: 98% | NPV: 91% | ||
| Pairs obtained on same day (N = 323) | |||
| BMApos | 115 | 12 | Sn: 91 |
| BMAneg | 4 | 192 | Sp: 98 |
| PPV: 97% | NPV: 94% | ||
| Pairs before HCT (N = 32) | |||
| BMApos | 9 | 1 | Sn: 90 |
| BMAneg | 0 | 22 | Sp: 100 |
| PPV: 100% | NPV: 96% | ||
| Pairs within 90 days after HCT (N = 64) | |||
| BMApos | 26 | 7 | Sn: 79 |
| BMAneg | 1 | 30 | Sp: 97 |
| PPV: 96% | NPV: 81% | ||
| Pairs with blasts <5% by both MFC and morphology (N = 209) | |||
| BMApos | 60 | 12 | Sn: 83 |
| BMAneg | 7 | 130 | Sp: 95 |
| PPV: 90% | NPV: 92% | ||
| Pairs with blasts <5% by both MFC and morphology with 0.1% abnormal blasts as cutoff (N = 209) | |||
| BMApos | 39 | 24 | Sn: 62 |
| BMAneg | 5 | 141 | Sp: 97 |
| PPV: 89% | NPV: 85% |
| . | PBpos . | PBneg . | Sn/Sp (%) . |
|---|---|---|---|
| All sample pairs (N = 724) | |||
| BMApos | 327 | 28 | Sn: 92 |
| BMAneg | 10 | 359 | Sp: 97 |
| PPV: 97% | NPV: 93% | ||
| First pair for each patient (N = 477) | |||
| BMApos | 242 | 21 | Sn: 92 |
| BMAneg | 6 | 208 | Sp: 97 |
| PPV: 98% | NPV: 91% | ||
| Pairs obtained on same day (N = 323) | |||
| BMApos | 115 | 12 | Sn: 91 |
| BMAneg | 4 | 192 | Sp: 98 |
| PPV: 97% | NPV: 94% | ||
| Pairs before HCT (N = 32) | |||
| BMApos | 9 | 1 | Sn: 90 |
| BMAneg | 0 | 22 | Sp: 100 |
| PPV: 100% | NPV: 96% | ||
| Pairs within 90 days after HCT (N = 64) | |||
| BMApos | 26 | 7 | Sn: 79 |
| BMAneg | 1 | 30 | Sp: 97 |
| PPV: 96% | NPV: 81% | ||
| Pairs with blasts <5% by both MFC and morphology (N = 209) | |||
| BMApos | 60 | 12 | Sn: 83 |
| BMAneg | 7 | 130 | Sp: 95 |
| PPV: 90% | NPV: 92% | ||
| Pairs with blasts <5% by both MFC and morphology with 0.1% abnormal blasts as cutoff (N = 209) | |||
| BMApos | 39 | 24 | Sn: 62 |
| BMAneg | 5 | 141 | Sp: 97 |
| PPV: 89% | NPV: 85% |
Sensitivity is the proportion of cases that are MRDpos in BMA and are also MRDpos in PB. Specificity is proportion of cases that are MRDneg in BMA and are also MRDneg in PB. PPV is the proportion of cases that are MRDpos in PB and are also MRDpos in BMA. NPV is the proportion of cases that are MRDneg in PB that are also MRDneg in BMA.
Sn, sensitivity; Sp, specificity.