Clonal hematopoiesis mutational frequency and genes mutated in ECD patients
| . | No. of patients with mutations, n (% among 51 patients) . | No. of mutations, n (% among 123 mutations) . |
|---|---|---|
| TET2 | 27 (53) | 47 (38) |
| ASXL1 | 11 (22) | 13 (11) |
| DNMT3A | 9 (18) | 10 (8) |
| NRAS | 7 (14) | 9 (7) |
| CBL | 6 (12) | 6 (5) |
| JAK2 | 5 (10) | 5 (4) |
| KRAS | 4 (8) | 5 (4) |
| SRSF2 | 4 (8) | 4 (3) |
| ZRSR2 | 4 (8) | 4 (3) |
| CALR | 3 (6) | 3 (2) |
| TP53 | 3 (6) | 3 (2) |
| EZH2 | 2 (4) | 2 (2) |
| SF3B1 | 2 (4) | 2 (2) |
| SMC1A | 2 (4) | 2 (2) |
| U2AF1 (U2AF35) | 2 (4) | 2 (2) |
| IDH2 | 1 (2) | 1 (1) |
| ETV6 | 1 (2) | 1 (1) |
| MPL | 1 (2) | 1 (1) |
| NMP1 | 1 (2) | 1 (1) |
| PHF6 | 1 (2) | 1 (1) |
| RIT1 | 1 (2) | 1 (1) |
| BCOR | 0 | 0 |
| BCORL1 | 0 | 0 |
| CSF3R | 0 | 0 |
| FLT3 (-TKD) | 0 | 0 |
| GATA | 0 | 0 |
| IDH1 | 0 | 0 |
| KIT | 0 | 0 |
| NIPBL | 0 | 0 |
| PTPN11 | 0 | 0 |
| RAD21 | 0 | 0 |
| RUNX1 (AML1) | 0 | 0 |
| SETBP1 | 0 | 0 |
| SMC3 | 0 | 0 |
| STAG2 | 0 | 0 |
| WT1 | 0 | 0 |
| Total | 97 | 123 |
| . | No. of patients with mutations, n (% among 51 patients) . | No. of mutations, n (% among 123 mutations) . |
|---|---|---|
| TET2 | 27 (53) | 47 (38) |
| ASXL1 | 11 (22) | 13 (11) |
| DNMT3A | 9 (18) | 10 (8) |
| NRAS | 7 (14) | 9 (7) |
| CBL | 6 (12) | 6 (5) |
| JAK2 | 5 (10) | 5 (4) |
| KRAS | 4 (8) | 5 (4) |
| SRSF2 | 4 (8) | 4 (3) |
| ZRSR2 | 4 (8) | 4 (3) |
| CALR | 3 (6) | 3 (2) |
| TP53 | 3 (6) | 3 (2) |
| EZH2 | 2 (4) | 2 (2) |
| SF3B1 | 2 (4) | 2 (2) |
| SMC1A | 2 (4) | 2 (2) |
| U2AF1 (U2AF35) | 2 (4) | 2 (2) |
| IDH2 | 1 (2) | 1 (1) |
| ETV6 | 1 (2) | 1 (1) |
| MPL | 1 (2) | 1 (1) |
| NMP1 | 1 (2) | 1 (1) |
| PHF6 | 1 (2) | 1 (1) |
| RIT1 | 1 (2) | 1 (1) |
| BCOR | 0 | 0 |
| BCORL1 | 0 | 0 |
| CSF3R | 0 | 0 |
| FLT3 (-TKD) | 0 | 0 |
| GATA | 0 | 0 |
| IDH1 | 0 | 0 |
| KIT | 0 | 0 |
| NIPBL | 0 | 0 |
| PTPN11 | 0 | 0 |
| RAD21 | 0 | 0 |
| RUNX1 (AML1) | 0 | 0 |
| SETBP1 | 0 | 0 |
| SMC3 | 0 | 0 |
| STAG2 | 0 | 0 |
| WT1 | 0 | 0 |
| Total | 97 | 123 |