Association of IFNL4 polymorphisms with HRs and MRs at 36-month follow-up of ropeg treatment
| Variant/diplotype . | Genotype/diplotype status . | n . | NR, n . | R, n . | % R . | OR (95% CI) . | P . |
|---|---|---|---|---|---|---|---|
| Influence of IFNL4 individual variants on HR in ropeg treatment of PV | |||||||
| rs8099917 | Non-TT | 29 | 8 | 21 | 72.4 | ||
| TT | 49 | 7 | 42 | 85.7 | 2.26 (0.62-8.45) | .2336 | |
| rs12979860 | Non-CC | 48 | 10 | 38 | 79.2 | ||
| CC | 31 | 5 | 26 | 83.9 | 1.36 (0.37-5.70) | .7710 | |
| rs368234815 | Non-TT | 48 | 10 | 38 | 79.2 | ||
| TT | 31 | 5 | 26 | 83.9 | 1.36 (0.37-5.70) | .7710 | |
| rs117648444 | GG | 58 | 13 | 45 | 77.6 | ||
| GA | 21 | 2 | 19 | 90.5 | 2.71 (0.53-27.11) | .3303 | |
| Influence of IFNL4 individual variants on MR in ropeg treatment of PV | |||||||
| rs8099917 | Non-T/T | 28 | 14 | 14 | 50.0 | ||
| T/T | 40 | 7 | 33 | 82.5 | 4.60 (1.39-16.69) | .0071 | |
| rs12979860 | Non-C/C | 41 | 18 | 23 | 56.1 | ||
| C/C | 27 | 3 | 24 | 88.9 | 6.10 (1.49-36.64) | .0065 | |
| rs368234815 | Non-TT/TT | 41 | 18 | 23 | 56.1 | ||
| TT/TT | 27 | 3 | 24 | 88.9 | 6.10 (1.49-36.64) | .0065 | |
| rs117648444 | G/G | 53 | 18 | 35 | 66.0 | ||
| G/A | 15 | 3 | 12 | 80.0 | 2.04 (0.46-12.68) | .3609 | |
| Influence of IFNL4 diplotypes on HR in ropeg treatment of PV | |||||||
| IFNL4-P70 alone* | P/N and P/P | 27 | 8 | 19 | 70.4 | Reference | |
| IFNL4-S70 and S70/P70* | N/S and P/S | 21 | 2 | 19 | 90.5 | 3.89 (0.66-42.31) | .1518 |
| No IFNL4* | N/N | 32 | 5 | 27 | 84.4 | 2.24 (0.55-10.16) | .2236 |
| No IFNL4† | N/N | 32 | 5 | 27 | 84.4 | Reference | |
| IFNL4-S70 and S70/P70† | N/S and P/S | 21 | 2 | 19 | 90.5 | 1.74 (0.25-20.11) | .6897 |
| Influence of IFNL4 diplotypes on MR in ropeg treatment of PV | |||||||
| IFNL4-P70 alone* | P/N and P/P | 26 | 15 | 11 | 42.3 | Reference | |
| IFNL4-S70 and S70/P70* | N/S and P/S | 15 | 3 | 12 | 80.0 | 5.23 (1.06 35.87) | .0254 |
| No IFNL4* | N/N | 28 | 3 | 25 | 89.3 | 10.80(2.39-69.97) | 3.91E-04 |
| no IFNL4† | N/N | 28 | 3 | 25 | 89.3 | Reference | |
| IFNL4-S70 and S70/P70† | N/S and P/S | 15 | 3 | 12 | 80.0 | 0.49 (0.06-4.20) | .6474 |
| Variant/diplotype . | Genotype/diplotype status . | n . | NR, n . | R, n . | % R . | OR (95% CI) . | P . |
|---|---|---|---|---|---|---|---|
| Influence of IFNL4 individual variants on HR in ropeg treatment of PV | |||||||
| rs8099917 | Non-TT | 29 | 8 | 21 | 72.4 | ||
| TT | 49 | 7 | 42 | 85.7 | 2.26 (0.62-8.45) | .2336 | |
| rs12979860 | Non-CC | 48 | 10 | 38 | 79.2 | ||
| CC | 31 | 5 | 26 | 83.9 | 1.36 (0.37-5.70) | .7710 | |
| rs368234815 | Non-TT | 48 | 10 | 38 | 79.2 | ||
| TT | 31 | 5 | 26 | 83.9 | 1.36 (0.37-5.70) | .7710 | |
| rs117648444 | GG | 58 | 13 | 45 | 77.6 | ||
| GA | 21 | 2 | 19 | 90.5 | 2.71 (0.53-27.11) | .3303 | |
| Influence of IFNL4 individual variants on MR in ropeg treatment of PV | |||||||
| rs8099917 | Non-T/T | 28 | 14 | 14 | 50.0 | ||
| T/T | 40 | 7 | 33 | 82.5 | 4.60 (1.39-16.69) | .0071 | |
| rs12979860 | Non-C/C | 41 | 18 | 23 | 56.1 | ||
| C/C | 27 | 3 | 24 | 88.9 | 6.10 (1.49-36.64) | .0065 | |
| rs368234815 | Non-TT/TT | 41 | 18 | 23 | 56.1 | ||
| TT/TT | 27 | 3 | 24 | 88.9 | 6.10 (1.49-36.64) | .0065 | |
| rs117648444 | G/G | 53 | 18 | 35 | 66.0 | ||
| G/A | 15 | 3 | 12 | 80.0 | 2.04 (0.46-12.68) | .3609 | |
| Influence of IFNL4 diplotypes on HR in ropeg treatment of PV | |||||||
| IFNL4-P70 alone* | P/N and P/P | 27 | 8 | 19 | 70.4 | Reference | |
| IFNL4-S70 and S70/P70* | N/S and P/S | 21 | 2 | 19 | 90.5 | 3.89 (0.66-42.31) | .1518 |
| No IFNL4* | N/N | 32 | 5 | 27 | 84.4 | 2.24 (0.55-10.16) | .2236 |
| No IFNL4† | N/N | 32 | 5 | 27 | 84.4 | Reference | |
| IFNL4-S70 and S70/P70† | N/S and P/S | 21 | 2 | 19 | 90.5 | 1.74 (0.25-20.11) | .6897 |
| Influence of IFNL4 diplotypes on MR in ropeg treatment of PV | |||||||
| IFNL4-P70 alone* | P/N and P/P | 26 | 15 | 11 | 42.3 | Reference | |
| IFNL4-S70 and S70/P70* | N/S and P/S | 15 | 3 | 12 | 80.0 | 5.23 (1.06 35.87) | .0254 |
| No IFNL4* | N/N | 28 | 3 | 25 | 89.3 | 10.80(2.39-69.97) | 3.91E-04 |
| no IFNL4† | N/N | 28 | 3 | 25 | 89.3 | Reference | |
| IFNL4-S70 and S70/P70† | N/S and P/S | 15 | 3 | 12 | 80.0 | 0.49 (0.06-4.20) | .6474 |
P values by Fisher’s exact test.
N, no IFNL4; NR, nonresponder; P, IFNL4-P70; R, responder; S, IFNL4-S70.
Contribution of IFNL4-S70 (IFNL4-S70 alone + IFNL4-S70/P70) and no-IFNL4, compared with that of IFNL4-P70 alone.
Contribution of IFNL4-S70 (IFNL4-S70 alone + IFNL4-S70/P70), compared with that of no-IFNL4.