Differently abundant proteins between plasma from patients with GPS and healthy controls
| Description . | Symbol . | Direction . | SG/GG . |
|---|---|---|---|
| α-Actinin-4 | ACTN4 | Up | 0 |
| CD5 antigen-like | CD5L | Up | 0 |
| Carbonic anhydrase 1 | CA1 | Down | 0 |
| Apolipoprotein C-I | APOC1 | Down | 0 |
| Apolipoprotein C-III | APOC3 | Down | 0 |
| C-reactive protein | CRP | Up | 0 |
| Apolipoprotein D | APOD | Down | 0 |
| Coagulation factor XIII B chain | F13B | Down | 0 |
| Tetranectin | CLEC3B | Down | 0 |
| Gelsolin | GSN | Down | 0 |
| Vitamin K–dependent protein S | PROS1 | Down | 0 |
| Complement C8 β chain | C8B | Down | 0 |
| Complement C8 γ chain | C8G | Down | 0 |
| 60-kDa HSP, mitochondrial | HSPD1 | Up | 0 |
| Histidine-tRNA ligase, cytoplasmic | HARS | Down | 0 |
| Xaa-Pro dipeptidase | PEPD | Down | 0 |
| Bone marrow proteoglycan | PRG2 | Up | 1 |
| Lipopolysaccharide-binding protein | LBP | Up | 0 |
| Glutathione peroxidase 3 | GPX3 | Down | 0 |
| Serum paraoxonase/arylesterase 1 | PON1 | Down | 0 |
| Peroxiredoxin-2 | PRDX2 | Down | 0 |
| Utrophin | UTRN | Down | 0 |
| Cathelicidin antimicrobial peptide | CAMP | Up | 1 |
| Cysteine-rich secretory protein 3 | CRISP3 | Up | 1 |
| Phospholipid transfer protein | PLTP | Down | 0 |
| Laminin subunit β-2 | LAMB2 | Down | 0 |
| Ras-related protein Rab-14 | RAB14 | Down | 0 |
| Lysozyme C | LYZ | Up | 1 |
| Hemoglobin subunit β | HBB | Down | 0 |
| Hemoglobin subunit α | HBA1/HBA2 | Down | 0 |
| Peptidyl-prolyl cis-trans isomerase FKBP5 | FKBP5 | Down | 0 |
| Apolipoprotein F | APOF | Down | 0 |
| Dihydropyrimidinase-related protein 2 | DPYSL2 | Down | 0 |
| Peptidyl-prolyl cis-trans isomerase CWC27 homolog | CWC27 | Down | 0 |
| Proprotein convertase subtilisin/kexin type 9 | PCSK9 | Down | 0 |
| Mediator of RNA polymerase II transcription subunit 30 | MED30 | Down | 0 |
| β-Ala-His dipeptidase | CNDP1 | Down | 0 |
| RuvB-like 2 | RUVBL2 | Down | 0 |
| Adseverin | SCIN | Down | 0 |
| Carbonic anhydrase 2 | CA2 | Down | 0 |
| Hemoglobin subunit δ | HBD | Down | 0 |
| Protein disulfide-isomerase A3 | PDI | Down | 0 |
| 40S ribosomal protein S19 | RPS19 | Down | 0 |
| Cadherin-13 | CDH13 | Down | 0 |
| Neutrophil gelatinase-associated lipocalin | NGAL/LCN2 | Up | 1 |
| Exportin-1 | XPO | Up | 0 |
| Platelet basic protein | PBP | Down | 0 |
| Thrombospondin-1 | THSB1 | Down | 0 |
| Flavin reductase (NADPH) | BLVRB | Down | 0 |
| T-complex protein 1 subunit γ | CCT3 | Down | 0 |
| Catalase | CAT | Down | 0 |
| Description . | Symbol . | Direction . | SG/GG . |
|---|---|---|---|
| α-Actinin-4 | ACTN4 | Up | 0 |
| CD5 antigen-like | CD5L | Up | 0 |
| Carbonic anhydrase 1 | CA1 | Down | 0 |
| Apolipoprotein C-I | APOC1 | Down | 0 |
| Apolipoprotein C-III | APOC3 | Down | 0 |
| C-reactive protein | CRP | Up | 0 |
| Apolipoprotein D | APOD | Down | 0 |
| Coagulation factor XIII B chain | F13B | Down | 0 |
| Tetranectin | CLEC3B | Down | 0 |
| Gelsolin | GSN | Down | 0 |
| Vitamin K–dependent protein S | PROS1 | Down | 0 |
| Complement C8 β chain | C8B | Down | 0 |
| Complement C8 γ chain | C8G | Down | 0 |
| 60-kDa HSP, mitochondrial | HSPD1 | Up | 0 |
| Histidine-tRNA ligase, cytoplasmic | HARS | Down | 0 |
| Xaa-Pro dipeptidase | PEPD | Down | 0 |
| Bone marrow proteoglycan | PRG2 | Up | 1 |
| Lipopolysaccharide-binding protein | LBP | Up | 0 |
| Glutathione peroxidase 3 | GPX3 | Down | 0 |
| Serum paraoxonase/arylesterase 1 | PON1 | Down | 0 |
| Peroxiredoxin-2 | PRDX2 | Down | 0 |
| Utrophin | UTRN | Down | 0 |
| Cathelicidin antimicrobial peptide | CAMP | Up | 1 |
| Cysteine-rich secretory protein 3 | CRISP3 | Up | 1 |
| Phospholipid transfer protein | PLTP | Down | 0 |
| Laminin subunit β-2 | LAMB2 | Down | 0 |
| Ras-related protein Rab-14 | RAB14 | Down | 0 |
| Lysozyme C | LYZ | Up | 1 |
| Hemoglobin subunit β | HBB | Down | 0 |
| Hemoglobin subunit α | HBA1/HBA2 | Down | 0 |
| Peptidyl-prolyl cis-trans isomerase FKBP5 | FKBP5 | Down | 0 |
| Apolipoprotein F | APOF | Down | 0 |
| Dihydropyrimidinase-related protein 2 | DPYSL2 | Down | 0 |
| Peptidyl-prolyl cis-trans isomerase CWC27 homolog | CWC27 | Down | 0 |
| Proprotein convertase subtilisin/kexin type 9 | PCSK9 | Down | 0 |
| Mediator of RNA polymerase II transcription subunit 30 | MED30 | Down | 0 |
| β-Ala-His dipeptidase | CNDP1 | Down | 0 |
| RuvB-like 2 | RUVBL2 | Down | 0 |
| Adseverin | SCIN | Down | 0 |
| Carbonic anhydrase 2 | CA2 | Down | 0 |
| Hemoglobin subunit δ | HBD | Down | 0 |
| Protein disulfide-isomerase A3 | PDI | Down | 0 |
| 40S ribosomal protein S19 | RPS19 | Down | 0 |
| Cadherin-13 | CDH13 | Down | 0 |
| Neutrophil gelatinase-associated lipocalin | NGAL/LCN2 | Up | 1 |
| Exportin-1 | XPO | Up | 0 |
| Platelet basic protein | PBP | Down | 0 |
| Thrombospondin-1 | THSB1 | Down | 0 |
| Flavin reductase (NADPH) | BLVRB | Down | 0 |
| T-complex protein 1 subunit γ | CCT3 | Down | 0 |
| Catalase | CAT | Down | 0 |
Results of the plasma proteomic analysis using SWATH-MS. Shown are the results of the comparison between plasma of patients with GPS (n = 11) and age-matched controls. A total of 51 discriminatory proteins were identified, with 11 proteins being more abundant (up direction) and 40 proteins being less abundant in plasma of patients with GPS (down direction) compared with plasma of healthy controls, as reported by Sims et al.26 Presence of SG proteins (5 proteins in total, indicated in bold and in the SG/GG column) in the plasma of GPS patients was found among other significantly increased plasma proteins.
HSP, heat shock protein.