Multivariate analysis on OS, ATL-related death, and TRM in each chromosomal abnormality
| . | . | . | OS . | . | . | ATL-related death . | . | . | TRM . | . |
|---|---|---|---|---|---|---|---|---|---|---|
| Chromosomal abnormalities . | n . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . |
| Numerical abnormalities | ||||||||||
| Loss | ||||||||||
| Chromosome 14 | 44 | — | — | NS | 2.01 | 1.229-3.303 | .006 | — | — | NS |
| Structural breakpoints | ||||||||||
| p-Arm | ||||||||||
| 3 | 29 | — | — | NS | 2.09 | 1.207-3.630 | .009 | — | — | NS |
| q-Arm | NS | |||||||||
| 1 | 50 | — | — | NS | 1.9 | 1.103-3.280 | .021 | — | — | NS |
| 2 | 42 | 1.63 | 1.115-2.375 | .012 | 1.72 | 1.046-2.816 | .033 | — | — | NS |
| 3 | 50 | — | — | NS | 1.73 | 1.057-2.842 | .029 | — | — | NS |
| 5 | 18 | 2.18 | 1.253-3.796 | .006 | 2.98 | 1.685-5.265 | <.001 | — | — | NS |
| 6 | 58 | — | — | NS | 1.88 | 1.148-3.063 | .012 | — | — | NS |
| 15 | 16 | — | — | NS | 2.33 | 1.139-4.762 | .021 | — | — | NS |
| . | . | . | OS . | . | . | ATL-related death . | . | . | TRM . | . |
|---|---|---|---|---|---|---|---|---|---|---|
| Chromosomal abnormalities . | n . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . |
| Numerical abnormalities | ||||||||||
| Loss | ||||||||||
| Chromosome 14 | 44 | — | — | NS | 2.01 | 1.229-3.303 | .006 | — | — | NS |
| Structural breakpoints | ||||||||||
| p-Arm | ||||||||||
| 3 | 29 | — | — | NS | 2.09 | 1.207-3.630 | .009 | — | — | NS |
| q-Arm | NS | |||||||||
| 1 | 50 | — | — | NS | 1.9 | 1.103-3.280 | .021 | — | — | NS |
| 2 | 42 | 1.63 | 1.115-2.375 | .012 | 1.72 | 1.046-2.816 | .033 | — | — | NS |
| 3 | 50 | — | — | NS | 1.73 | 1.057-2.842 | .029 | — | — | NS |
| 5 | 18 | 2.18 | 1.253-3.796 | .006 | 2.98 | 1.685-5.265 | <.001 | — | — | NS |
| 6 | 58 | — | — | NS | 1.88 | 1.148-3.063 | .012 | — | — | NS |
| 15 | 16 | — | — | NS | 2.33 | 1.139-4.762 | .021 | — | — | NS |
Clinical variables using multivariate analysis of each of the chromosomal abnormalities were age, sex, ATL disease type, disease status, and level of soluble IL2 receptor. P values of significant factors extracted by the Holm method are in bold.
p-arm, short arm of the chromosome; q-arm, long arm of the chromosome; NS, no statistically significant difference.