Risk of bone toxicities by the levels of African ancestry in the genotyped subcohort of the DFCI 05-001 trial
| . | No. of toxicities (%) . | Unadjusted model . | Adjusted model* . | |||
|---|---|---|---|---|---|---|
| Yes . | No . | SHR (95% CI) . | P . | SHR (95% CI) . | P . | |
| Fracture | ||||||
| Level 1 (<0.024) | 94 (84.7) | 221 (65.4) | 1.00 | 1.00 | ||
| Level 2 (0.024-0.066) | 10 (9.0) | 35 (10.4) | 0.71 (0.38-1.34) | .29 | 0.72 (0.39-1.35) | .31 |
| Level 3 (0.067-0.272) | 4 (3.6) | 41 (12.1) | 0.28 (0.10-0.77) | .01 | 0.29 (0.10-0.81) | .02 |
| Level 4 (>0.272) | 3 (2.7) | 41 (12.1) | 0.20 (0.07-0.63) | .006 | 0.19 (0.06-0.58) | .003 |
| Osteonecrosis | ||||||
| Level 1 (<0.024) | 41 (91.1) | 274 (67.8) | 1.00 | 1.00 | ||
| Level 2 (0.024-0.066) | 2 (4.4) | 43 (10.6) | 0.33 (0.08-1.36) | .12 | 0.32 (0.08-1.25) | .10 |
| Level 3 (0.067-0.272) | 1 (2.2) | 44 (10.9) | 0.16 (0.02-1.16) | .07 | 0.15 (0.02-1.14) | .07 |
| Level 4 (>0.272) | 1 (2.2) | 43 (10.6) | 0.16 (0.02-1.16) | .07 | 0.14 (0.02-0.92) | .04 |
| . | No. of toxicities (%) . | Unadjusted model . | Adjusted model* . | |||
|---|---|---|---|---|---|---|
| Yes . | No . | SHR (95% CI) . | P . | SHR (95% CI) . | P . | |
| Fracture | ||||||
| Level 1 (<0.024) | 94 (84.7) | 221 (65.4) | 1.00 | 1.00 | ||
| Level 2 (0.024-0.066) | 10 (9.0) | 35 (10.4) | 0.71 (0.38-1.34) | .29 | 0.72 (0.39-1.35) | .31 |
| Level 3 (0.067-0.272) | 4 (3.6) | 41 (12.1) | 0.28 (0.10-0.77) | .01 | 0.29 (0.10-0.81) | .02 |
| Level 4 (>0.272) | 3 (2.7) | 41 (12.1) | 0.20 (0.07-0.63) | .006 | 0.19 (0.06-0.58) | .003 |
| Osteonecrosis | ||||||
| Level 1 (<0.024) | 41 (91.1) | 274 (67.8) | 1.00 | 1.00 | ||
| Level 2 (0.024-0.066) | 2 (4.4) | 43 (10.6) | 0.33 (0.08-1.36) | .12 | 0.32 (0.08-1.25) | .10 |
| Level 3 (0.067-0.272) | 1 (2.2) | 44 (10.9) | 0.16 (0.02-1.16) | .07 | 0.15 (0.02-1.14) | .07 |
| Level 4 (>0.272) | 1 (2.2) | 43 (10.6) | 0.16 (0.02-1.16) | .07 | 0.14 (0.02-0.92) | .04 |
The 4 levels of African ancestry were determined on the basis of the distribution of the data, most of which was close to zero and was categorized as level 1; the rest were categorized into 3 levels with approximately equal numbers of patients. The numbers in the parentheses indicate the cutoff points of the proportion of African ancestry an individual carries that ranges between 0 and 1.
Death and recurrence were considered competing risks. Adjusted covariates included age, sex, and final risk group.