Parameters of thrombin generation according to free TFPIα values (<95th vs ≥95th percentile of the healthy controls)
| . | Free TFPIα <95th percentile, <15.4 ng/mL, median [IQR] . | Free TFPIα ≥95th percentile, ≥15.4 ng/mL, median [IQR] . | P . | BHC . |
|---|---|---|---|---|
| All patients | n = 549 | n = 71 | ||
| Lag time, min | 10.6 [9.1-12.6] | 12.1 [10.6-13.6] | <.001 | <.05 |
| Velocity index, nmol/L per min | 29.7 [15.8-51.6] | 29.6 [14.8-44.8] | .483 | ns |
| Peak thrombin, nmol/L | 224.6 [150.7-309.8] | 233.6 [153.2-287.3] | .493 | ns |
| TTP, min | 18.1 [15.6-22.1] | 19.6 [16.6-24.0] | .021 | ns |
| AUC, nmol/L × min | 3207.8 [2788.5-3686.9] | 3214.0 [2755.5-3603.1] | .612 | ns |
| BUC | n = 371 | n = 49 | ||
| Lag time, min | 10.6 [9.1-12.1] | 12.1 [10.6-13.6] | .001 | <.05 |
| Velocity index, nmol/L per min | 34.8 [18.0-58.3] | 31.4 [19.8-44.8] | .315 | ns |
| Peak thrombin, nmol/L | 240.7 [161.4-335.8] | 235.1 [158.0-289.8] | .212 | ns |
| TTP, min | 17.6 [15.1-21.6] | 19.1 [16.1-23.1] | .047 | ns |
| AUC, nmol/L × min | 3293.2 [2855.3-3792.3] | 3158.2 [2759.3-3571.9] | .137 | ns |
| PFD | n = 102 | n = 15 | ||
| Lag time, min | 11.1 [10.1-12.6] | 13.5 [11.6-14.4] | .010 | <.05 |
| Velocity index, nmol/L per min | 28.4 [17.8-47.1] | 26.3 [10.7-39.2] | .361 | ns |
| Peak thrombin, nmol/L | 213.6 [151.5-282.8] | 214.7 [109.4-263.9] | .464 | ns |
| TTP, min | 18.6 [16.6-21.6] | 21.1 [19.1-24.5] | .036 | ns |
| AUC, nmol/L × min | 3092.0 [2817.5-3662.1] | 3346 [2612-3632.1] | .822 | ns |
| . | Free TFPIα <95th percentile, <15.4 ng/mL, median [IQR] . | Free TFPIα ≥95th percentile, ≥15.4 ng/mL, median [IQR] . | P . | BHC . |
|---|---|---|---|---|
| All patients | n = 549 | n = 71 | ||
| Lag time, min | 10.6 [9.1-12.6] | 12.1 [10.6-13.6] | <.001 | <.05 |
| Velocity index, nmol/L per min | 29.7 [15.8-51.6] | 29.6 [14.8-44.8] | .483 | ns |
| Peak thrombin, nmol/L | 224.6 [150.7-309.8] | 233.6 [153.2-287.3] | .493 | ns |
| TTP, min | 18.1 [15.6-22.1] | 19.6 [16.6-24.0] | .021 | ns |
| AUC, nmol/L × min | 3207.8 [2788.5-3686.9] | 3214.0 [2755.5-3603.1] | .612 | ns |
| BUC | n = 371 | n = 49 | ||
| Lag time, min | 10.6 [9.1-12.1] | 12.1 [10.6-13.6] | .001 | <.05 |
| Velocity index, nmol/L per min | 34.8 [18.0-58.3] | 31.4 [19.8-44.8] | .315 | ns |
| Peak thrombin, nmol/L | 240.7 [161.4-335.8] | 235.1 [158.0-289.8] | .212 | ns |
| TTP, min | 17.6 [15.1-21.6] | 19.1 [16.1-23.1] | .047 | ns |
| AUC, nmol/L × min | 3293.2 [2855.3-3792.3] | 3158.2 [2759.3-3571.9] | .137 | ns |
| PFD | n = 102 | n = 15 | ||
| Lag time, min | 11.1 [10.1-12.6] | 13.5 [11.6-14.4] | .010 | <.05 |
| Velocity index, nmol/L per min | 28.4 [17.8-47.1] | 26.3 [10.7-39.2] | .361 | ns |
| Peak thrombin, nmol/L | 213.6 [151.5-282.8] | 214.7 [109.4-263.9] | .464 | ns |
| TTP, min | 18.6 [16.6-21.6] | 21.1 [19.1-24.5] | .036 | ns |
| AUC, nmol/L × min | 3092.0 [2817.5-3662.1] | 3346 [2612-3632.1] | .822 | ns |
Bold values in the table body represent statistically significant results.
ns, not significant.