Free TFPIα values in comparison with healthy controls, and number and odds of patients with high free TFPIα levels in all patients and according to the established diagnoses
| . | . | Free TFPIα, ng/mL . | Free TFPIα ≥95th percentile, ≥15.4 ng/mL . | ||
|---|---|---|---|---|---|
| n (%) . | Median [IQR] . | P* . | n (%) . | OR† [95% CI] . | |
| Healthy controls | 100 (100) | 7.8 [4.3-11.1] | na | 5 (5) | na |
| All patients‡ | 620 (100) | 8.2 [5.5-11.7] | .026 | 71 (11.5) | 2.82 [0.98-8.13] |
| BUC | 420 (67.7) | 8.3 [5.5-12.0] | .025 | 49 (11.6) | 3.03 [1.02-8.98] |
| PFD§ | 121 (19.5) | 8.9 [5.7-12.0] | .014 | 15 (12.4) | 3.47 [1.09-11.08] |
| VWF:Ag and/or VWF:RCo ≤ 50 U/mL§ | 57 (9.2) | 6.9 [4.5-9.3] | .634 | 4 (7.0) | 2.07 [0.47-9.09] |
| CFD | 23 (3.7) | 7.1 [5.7-11.8] | .529 | 3 (13.0) | 2.02 [0.26-15.49] |
| . | . | Free TFPIα, ng/mL . | Free TFPIα ≥95th percentile, ≥15.4 ng/mL . | ||
|---|---|---|---|---|---|
| n (%) . | Median [IQR] . | P* . | n (%) . | OR† [95% CI] . | |
| Healthy controls | 100 (100) | 7.8 [4.3-11.1] | na | 5 (5) | na |
| All patients‡ | 620 (100) | 8.2 [5.5-11.7] | .026 | 71 (11.5) | 2.82 [0.98-8.13] |
| BUC | 420 (67.7) | 8.3 [5.5-12.0] | .025 | 49 (11.6) | 3.03 [1.02-8.98] |
| PFD§ | 121 (19.5) | 8.9 [5.7-12.0] | .014 | 15 (12.4) | 3.47 [1.09-11.08] |
| VWF:Ag and/or VWF:RCo ≤ 50 U/mL§ | 57 (9.2) | 6.9 [4.5-9.3] | .634 | 4 (7.0) | 2.07 [0.47-9.09] |
| CFD | 23 (3.7) | 7.1 [5.7-11.8] | .529 | 3 (13.0) | 2.02 [0.26-15.49] |
Bold values in the table body represent statistically significant results.
Adjusted for age, sex and BMI in multivariate analysis.
Adjusted for age, sex and BMI in logistic regression.
Three patients with hypo-/dysfibrinogenemia were not evaluated separately due to the low number.
Four patients had both a PFD and VWF ≤50 U/mL, they were included in both subgroups for analysis.