Hematologic parameters in DICER1 carriers and controls excluding those receiving chemotherapy or radiation within 2 years of evaluation
| Parameter . | Controls (n = 64) . | DICER1 carriers (n = 114) . | P . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Low . | Not low . | Low . | Not low . | ||||||
| No. . | % . | No. . | % . | No. . | % . | No. . | % . | ||
| Blood count indices | |||||||||
| WBCs | 2 | 3.2 | 61 | 96.8 | 14 | 12.3 | 100 | 87.7 | .043* |
| RBCs | 8 | 12.7 | 55 | 87.3 | 7 | 6.1 | 107 | 93.9 | .134* |
| Hgb | 6 | 9.5 | 57 | 90.5 | 8 | 7 | 106 | 93 | .57 |
| Hematocrit | 3 | 4.8 | 60 | 95.2 | 5 | 4.4 | 109 | 95.6 | 1 |
| MCV | 1 | 1.6 | 62 | 98.4 | 1 | 0.9 | 113 | 99.1 | 1 |
| MCH | 1 | 1.6 | 62 | 98.4 | 0 | 0 | 114 | 100 | .356 |
| MCHC | 5 | 7.9 | 58 | 92.1 | 6 | 5.3 | 108 | 94.7 | .524 |
| RDW | 2 | 3.2 | 61 | 96.8 | 1 | 0.9 | 113 | 99.1 | .289 |
| Platelet count | 5 | 7.9 | 58 | 92.1 | 8 | 7.1 | 105 | 92.9 | 1 |
| MPV | 4 | 6.5 | 58 | 93.5 | 14 | 12.4 | 99 | 87.6 | .216* |
| Nucleated RBCs | 0 | 0 | 60 | 100 | 0 | 0 | 107 | 100 | NA |
| Absolute nucleated RBCs | 1 | 1.6 | 62 | 98.4 | 10 | 8.8 | 104 | 91.2 | 1 |
| Reticulocytes | 2 | 3.2 | 61 | 96.8 | 3 | 2.6 | 111 | 97.4 | 1 |
| Absolute reticulocyte count | 1 | 1.6 | 62 | 98.4 | 3 | 2.6 | 111 | 97.4 | 1 |
| Reticulocyte Hgb | 1 | 1.6 | 62 | 98.4 | 4 | 3.5 | 110 | 96.5 | .657 |
| Immature platelet fraction | 2 | 3.2 | 61 | 96.8 | 4 | 3.6 | 108 | 96.4 | 1 |
| Immature reticulocyte fraction | 4 | 11.4 | 31 | 88.6 | 1 | 1.6 | 63 | 98.4 | .051 |
| Differentials | |||||||||
| Absolute neutrophil count | 1 | 1.6 | 62 | 98.4 | 10 | 8.8 | 104 | 91.2 | 1 |
| Absolute immature granulocytes | 0 | 0 | 51 | 100 | 0 | 0 | 88 | 100 | NA |
| Absolute lymphocytes | 3 | 4.8 | 60 | 95.2 | 8 | 7 | 106 | 93 | .749 |
| Absolute monocytes | 2 | 3.2 | 61 | 96.8 | 3 | 2.6 | 111 | 97.4 | 1 |
| Absolute eosinophils | 0 | 0 | 63 | 100 | 6 | 5.3 | 108 | 94.7 | .09 |
| Absolute basophil count | 3 | 4.8 | 60 | 95.2 | 7 | 6.1 | 107 | 93.9 | 1 |
| Iron indices | |||||||||
| Iron | 2 | 14.3 | 12 | 85.7 | 3 | 10.3 | 26 | 89.7 | 1 |
| Transferrin | 0 | 0 | 14 | 100 | 0 | 0 | 29 | 100 | NA |
| Iron saturation | 4 | 28.6 | 10 | 71.4 | 11 | 37.9 | 18 | 62.1 | .735 |
| Ferritin | 6 | 9.5 | 57 | 90.5 | 23 | 20.2 | 91 | 79.8 | .067* |
| Other indices | |||||||||
| Erythrocyte sedimentation rate | 0 | 0 | 42 | 100 | 0 | 0 | 76 | 100 | NA |
| Fetal Hgb | 0 | 0 | 52 | 100 | 0 | 0 | 101 | 100 | NA |
| Erythropoietin | 0 | 0 | 56 | 100 | 0 | 0 | 104 | 100 | NA |
| Lactate dehydrogenase | 0 | 0 | 61 | 100 | 3 | 2.7 | 108 | 97.3 | .533 |
| Parameter . | Controls (n = 64) . | DICER1 carriers (n = 114) . | P . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Low . | Not low . | Low . | Not low . | ||||||
| No. . | % . | No. . | % . | No. . | % . | No. . | % . | ||
| Blood count indices | |||||||||
| WBCs | 2 | 3.2 | 61 | 96.8 | 14 | 12.3 | 100 | 87.7 | .043* |
| RBCs | 8 | 12.7 | 55 | 87.3 | 7 | 6.1 | 107 | 93.9 | .134* |
| Hgb | 6 | 9.5 | 57 | 90.5 | 8 | 7 | 106 | 93 | .57 |
| Hematocrit | 3 | 4.8 | 60 | 95.2 | 5 | 4.4 | 109 | 95.6 | 1 |
| MCV | 1 | 1.6 | 62 | 98.4 | 1 | 0.9 | 113 | 99.1 | 1 |
| MCH | 1 | 1.6 | 62 | 98.4 | 0 | 0 | 114 | 100 | .356 |
| MCHC | 5 | 7.9 | 58 | 92.1 | 6 | 5.3 | 108 | 94.7 | .524 |
| RDW | 2 | 3.2 | 61 | 96.8 | 1 | 0.9 | 113 | 99.1 | .289 |
| Platelet count | 5 | 7.9 | 58 | 92.1 | 8 | 7.1 | 105 | 92.9 | 1 |
| MPV | 4 | 6.5 | 58 | 93.5 | 14 | 12.4 | 99 | 87.6 | .216* |
| Nucleated RBCs | 0 | 0 | 60 | 100 | 0 | 0 | 107 | 100 | NA |
| Absolute nucleated RBCs | 1 | 1.6 | 62 | 98.4 | 10 | 8.8 | 104 | 91.2 | 1 |
| Reticulocytes | 2 | 3.2 | 61 | 96.8 | 3 | 2.6 | 111 | 97.4 | 1 |
| Absolute reticulocyte count | 1 | 1.6 | 62 | 98.4 | 3 | 2.6 | 111 | 97.4 | 1 |
| Reticulocyte Hgb | 1 | 1.6 | 62 | 98.4 | 4 | 3.5 | 110 | 96.5 | .657 |
| Immature platelet fraction | 2 | 3.2 | 61 | 96.8 | 4 | 3.6 | 108 | 96.4 | 1 |
| Immature reticulocyte fraction | 4 | 11.4 | 31 | 88.6 | 1 | 1.6 | 63 | 98.4 | .051 |
| Differentials | |||||||||
| Absolute neutrophil count | 1 | 1.6 | 62 | 98.4 | 10 | 8.8 | 104 | 91.2 | 1 |
| Absolute immature granulocytes | 0 | 0 | 51 | 100 | 0 | 0 | 88 | 100 | NA |
| Absolute lymphocytes | 3 | 4.8 | 60 | 95.2 | 8 | 7 | 106 | 93 | .749 |
| Absolute monocytes | 2 | 3.2 | 61 | 96.8 | 3 | 2.6 | 111 | 97.4 | 1 |
| Absolute eosinophils | 0 | 0 | 63 | 100 | 6 | 5.3 | 108 | 94.7 | .09 |
| Absolute basophil count | 3 | 4.8 | 60 | 95.2 | 7 | 6.1 | 107 | 93.9 | 1 |
| Iron indices | |||||||||
| Iron | 2 | 14.3 | 12 | 85.7 | 3 | 10.3 | 26 | 89.7 | 1 |
| Transferrin | 0 | 0 | 14 | 100 | 0 | 0 | 29 | 100 | NA |
| Iron saturation | 4 | 28.6 | 10 | 71.4 | 11 | 37.9 | 18 | 62.1 | .735 |
| Ferritin | 6 | 9.5 | 57 | 90.5 | 23 | 20.2 | 91 | 79.8 | .067* |
| Other indices | |||||||||
| Erythrocyte sedimentation rate | 0 | 0 | 42 | 100 | 0 | 0 | 76 | 100 | NA |
| Fetal Hgb | 0 | 0 | 52 | 100 | 0 | 0 | 101 | 100 | NA |
| Erythropoietin | 0 | 0 | 56 | 100 | 0 | 0 | 104 | 100 | NA |
| Lactate dehydrogenase | 0 | 0 | 61 | 100 | 3 | 2.7 | 108 | 97.3 | .533 |
Data excludes those individuals who received chemotherapy and/or radiation ≤2 years before their visit to the NIH Clinical Center. Percentages may not sum to 100% due to rounding. P values <.05 are shown in bold.
Designates χ2 instead of Fisher’s exact test.