ORs with 95% CIs for overall, provoked, and unprovoked DVT and PE, according to quartiles of plasma VWF level
| VTE subgroup . | Controls (n = 843) . | Cases . | Model 1 . | Model 2 . | Model 3 . |
|---|---|---|---|---|---|
| Overall DVT | n = 259 | ||||
| VWF Q1 | 210 | 53 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 57 | 1.08 (0.71-1.65) | 1.07 (0.70-1.64) | 1.06 (0.69-1.63) |
| VWF Q3 | 210 | 65 | 1.26 (0.83-1.90) | 1.26 (0.83-1.90) | 1.23 (0.81-1.87) |
| VWF Q4 | 212 | 84 | 1.63 (1.09-2.43) | 1.52 (1.01-2.29) | 1.49 (0.99-2.25) |
| P value for trend | 0.01 | 0.03 | 0.04 | ||
| Provoked DVT | n = 156 | ||||
| VWF Q1 | 210 | 45 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 36 | 0.79 (0.49-1.27) | 0.78 (0.48-1.27) | 0.78 (0.48-1.27) |
| VWF Q3 | 210 | 38 | 0.82 (0.51-1.33) | 0.83 (0.51-1.33) | 0.83 (0.51-1.34) |
| VWF Q4 | 212 | 37 | 0.78 (0-48-1.28) | 0.74 (0.45-1.21) | 0.74 (0.45-1.22) |
| P value for trend | .4 | .3 | .3 | ||
| Unprovoked DVT | n = 103 | ||||
| VWF Q1 | 210 | 8 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 21 | 2.73 (1.18-6.33) | 2.78 (1.19-6.47) | 2.73 (1.17-6.40) |
| VWF Q3 | 210 | 27 | 3.74 (1.65-8.47) | 3.79 (1.66-8.62) | 3.59 (1.57-8.23) |
| VWF Q4 | 212 | 47 | 6.73 (3.07-14.76) | 6.40 (2.90-14.12) | 6.18 (2.78-13.70) |
| P value for trend | <.001 | <.001 | <.001 | ||
| Overall PE | n = 155 | ||||
| VWF Q1 | 210 | 35 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 37 | 1.04 (0.63-1.72) | 0.96 (0.58-1.61) | 0.99 (0.59-1.67) |
| VWF Q3 | 210 | 40 | 1.12 (0.68-1.84) | 1.10 (0.67-1.83) | 1.15 (0.69-1.92) |
| VWF Q4 | 212 | 43 | 1.18 (0.72-1.93) | 1.11 (0.67-1.84) | 1.14 (0.69-1.91) |
| P value for trend | .5 | .6 | .5 | ||
| Provoked PE | n = 85 | ||||
| VWF Q1 | 210 | 17 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 20 | 1.15 (0.59-2.27) | 1.05 (0.53-2.10) | 1.14 (0.56-2.31) |
| VWF Q3 | 210 | 24 | 1.36 (0.70-2.63) | 1.32 (0.68-2.56) | 1.43 (0.72-2.83) |
| VWF Q4 | 212 | 24 | 1.33 (0.69-2.57) | 1.24 (0.63-2.42) | 1.33 (0.67-2.64) |
| P value for trend | .4 | .4 | .3 | ||
| Unprovoked PE | n = 70 | ||||
| VWF Q1 | 210 | 18 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 17 | 0.94 (0.47-1.88) | 0.90 (0.44-1.83) | 0.88 (0.43-1.80) |
| VWF Q3 | 210 | 16 | 0.89 (0.44-1.80) | 0.89 (0.43-1.82) | 0.89 (0.43-1.84) |
| VWF Q4 | 212 | 19 | 1.04 (0.52-2.08) | 0.98 (0.49-1.98) | 0.97 (0.48-1.96) |
| P value for trend | .9 | .9 | .9 |
| VTE subgroup . | Controls (n = 843) . | Cases . | Model 1 . | Model 2 . | Model 3 . |
|---|---|---|---|---|---|
| Overall DVT | n = 259 | ||||
| VWF Q1 | 210 | 53 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 57 | 1.08 (0.71-1.65) | 1.07 (0.70-1.64) | 1.06 (0.69-1.63) |
| VWF Q3 | 210 | 65 | 1.26 (0.83-1.90) | 1.26 (0.83-1.90) | 1.23 (0.81-1.87) |
| VWF Q4 | 212 | 84 | 1.63 (1.09-2.43) | 1.52 (1.01-2.29) | 1.49 (0.99-2.25) |
| P value for trend | 0.01 | 0.03 | 0.04 | ||
| Provoked DVT | n = 156 | ||||
| VWF Q1 | 210 | 45 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 36 | 0.79 (0.49-1.27) | 0.78 (0.48-1.27) | 0.78 (0.48-1.27) |
| VWF Q3 | 210 | 38 | 0.82 (0.51-1.33) | 0.83 (0.51-1.33) | 0.83 (0.51-1.34) |
| VWF Q4 | 212 | 37 | 0.78 (0-48-1.28) | 0.74 (0.45-1.21) | 0.74 (0.45-1.22) |
| P value for trend | .4 | .3 | .3 | ||
| Unprovoked DVT | n = 103 | ||||
| VWF Q1 | 210 | 8 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 21 | 2.73 (1.18-6.33) | 2.78 (1.19-6.47) | 2.73 (1.17-6.40) |
| VWF Q3 | 210 | 27 | 3.74 (1.65-8.47) | 3.79 (1.66-8.62) | 3.59 (1.57-8.23) |
| VWF Q4 | 212 | 47 | 6.73 (3.07-14.76) | 6.40 (2.90-14.12) | 6.18 (2.78-13.70) |
| P value for trend | <.001 | <.001 | <.001 | ||
| Overall PE | n = 155 | ||||
| VWF Q1 | 210 | 35 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 37 | 1.04 (0.63-1.72) | 0.96 (0.58-1.61) | 0.99 (0.59-1.67) |
| VWF Q3 | 210 | 40 | 1.12 (0.68-1.84) | 1.10 (0.67-1.83) | 1.15 (0.69-1.92) |
| VWF Q4 | 212 | 43 | 1.18 (0.72-1.93) | 1.11 (0.67-1.84) | 1.14 (0.69-1.91) |
| P value for trend | .5 | .6 | .5 | ||
| Provoked PE | n = 85 | ||||
| VWF Q1 | 210 | 17 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 20 | 1.15 (0.59-2.27) | 1.05 (0.53-2.10) | 1.14 (0.56-2.31) |
| VWF Q3 | 210 | 24 | 1.36 (0.70-2.63) | 1.32 (0.68-2.56) | 1.43 (0.72-2.83) |
| VWF Q4 | 212 | 24 | 1.33 (0.69-2.57) | 1.24 (0.63-2.42) | 1.33 (0.67-2.64) |
| P value for trend | .4 | .4 | .3 | ||
| Unprovoked PE | n = 70 | ||||
| VWF Q1 | 210 | 18 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 17 | 0.94 (0.47-1.88) | 0.90 (0.44-1.83) | 0.88 (0.43-1.80) |
| VWF Q3 | 210 | 16 | 0.89 (0.44-1.80) | 0.89 (0.43-1.82) | 0.89 (0.43-1.84) |
| VWF Q4 | 212 | 19 | 1.04 (0.52-2.08) | 0.98 (0.49-1.98) | 0.97 (0.48-1.96) |
| P value for trend | .9 | .9 | .9 |
Model 1: adjusted for age and sex. Model 2: model 1 + BMI and CRP. Model 3: model 2 + smoking, hypertension, and estrogen use.