Clinical characteristics of patients with UCD with and without MIS
. | MIS . | Non-MIS . | ||
---|---|---|---|---|
Patients, n . | n (%) . | Patients, n . | n (%) . | |
Constitutional symptoms* | 19 | 12 (63.2) | 97 | 8 (8.2) |
Hepatomegaly and/or splenomegaly | 19 | 10 (52.6) | 97 | 2 (2.1) |
Fluid accumulation† | 19 | 5 (26.3) | 97 | 1 (1.0) |
Anemia‡ | 18 | 13 (72.2) | 87 | 4 (4.6) |
Abnormal PLT§ | 18 | 9 (50.0) | 87 | 4 (4.6) |
Thrombocytosis | — | 6 (33.3) | — | 3 (3.4) |
Thrombocytopenia | — | 3 (16.7) | — | 1 (1.1) |
Albumin <35, g/L | 9 | 2 (22.2) | 30 | 0 (0.0) |
eGFR <60.00, mL/min per 1.73 m2 | 17 | 3 (17.6) | 83 | 0 (0.0) |
ESR >15, mm/h | 9 | 6 (66.7) | 22 | 5 (22.7) |
hsCRP >3.00, mg/L | 9 | 7 (77.8) | 22 | 4 (18.2) |
IgG >17.00, g/L | 12 | 7 (77.8) | 23 | 2 (8.7) |
IL-6 >5.9, pg/mL | 10 | 5 (50.0) | 20 | 2 (10.0) |
. | MIS . | Non-MIS . | ||
---|---|---|---|---|
Patients, n . | n (%) . | Patients, n . | n (%) . | |
Constitutional symptoms* | 19 | 12 (63.2) | 97 | 8 (8.2) |
Hepatomegaly and/or splenomegaly | 19 | 10 (52.6) | 97 | 2 (2.1) |
Fluid accumulation† | 19 | 5 (26.3) | 97 | 1 (1.0) |
Anemia‡ | 18 | 13 (72.2) | 87 | 4 (4.6) |
Abnormal PLT§ | 18 | 9 (50.0) | 87 | 4 (4.6) |
Thrombocytosis | — | 6 (33.3) | — | 3 (3.4) |
Thrombocytopenia | — | 3 (16.7) | — | 1 (1.1) |
Albumin <35, g/L | 9 | 2 (22.2) | 30 | 0 (0.0) |
eGFR <60.00, mL/min per 1.73 m2 | 17 | 3 (17.6) | 83 | 0 (0.0) |
ESR >15, mm/h | 9 | 6 (66.7) | 22 | 5 (22.7) |
hsCRP >3.00, mg/L | 9 | 7 (77.8) | 22 | 4 (18.2) |
IgG >17.00, g/L | 12 | 7 (77.8) | 23 | 2 (8.7) |
IL-6 >5.9, pg/mL | 10 | 5 (50.0) | 20 | 2 (10.0) |
Significant P values are in bold.
eGFR, estimated glomerular filtration rate; hsCRP, high-sensitivity C-reactive protein; PLT, platelet count.
Night sweats, fever (>39°C), weight loss, or fatigue (≥2 Common Terminology Criteria for Adverse Events lymphoma score for B-symptoms).
Edema, anasarca, ascites, or pleural effusion.
Hemoglobin: <12 g/dL in males, <11 g/dL in females.
Thrombocytopenia (PLT <100 k/μL) or thrombocytosis (PLT >350 k/μL).