Table 2.

Clinical characteristics of patients with UCD with and without MIS

MISNon-MIS
Patients, nn (%)Patients, nn (%)
Constitutional symptoms* 19 12 (63.2) 97 8 (8.2) 
Hepatomegaly and/or splenomegaly 19 10 (52.6) 97 2 (2.1) 
Fluid accumulation 19 5 (26.3) 97 1 (1.0) 
Anemia 18 13 (72.2) 87 4 (4.6) 
Abnormal PLT§ 18 9 (50.0) 87 4 (4.6) 
Thrombocytosis — 6 (33.3) — 3 (3.4) 
Thrombocytopenia — 3 (16.7) — 1 (1.1) 
Albumin <35, g/L 2 (22.2) 30 0 (0.0) 
eGFR <60.00, mL/min per 1.73 m2 17 3 (17.6) 83 0 (0.0) 
ESR >15, mm/h 6 (66.7) 22 5 (22.7) 
hsCRP >3.00, mg/L 7 (77.8) 22 4 (18.2) 
IgG >17.00, g/L 12 7 (77.8) 23 2 (8.7) 
IL-6 >5.9, pg/mL 10 5 (50.0) 20 2 (10.0) 
MISNon-MIS
Patients, nn (%)Patients, nn (%)
Constitutional symptoms* 19 12 (63.2) 97 8 (8.2) 
Hepatomegaly and/or splenomegaly 19 10 (52.6) 97 2 (2.1) 
Fluid accumulation 19 5 (26.3) 97 1 (1.0) 
Anemia 18 13 (72.2) 87 4 (4.6) 
Abnormal PLT§ 18 9 (50.0) 87 4 (4.6) 
Thrombocytosis — 6 (33.3) — 3 (3.4) 
Thrombocytopenia — 3 (16.7) — 1 (1.1) 
Albumin <35, g/L 2 (22.2) 30 0 (0.0) 
eGFR <60.00, mL/min per 1.73 m2 17 3 (17.6) 83 0 (0.0) 
ESR >15, mm/h 6 (66.7) 22 5 (22.7) 
hsCRP >3.00, mg/L 7 (77.8) 22 4 (18.2) 
IgG >17.00, g/L 12 7 (77.8) 23 2 (8.7) 
IL-6 >5.9, pg/mL 10 5 (50.0) 20 2 (10.0) 

Significant P values are in bold.

eGFR, estimated glomerular filtration rate; hsCRP, high-sensitivity C-reactive protein; PLT, platelet count.

*

Night sweats, fever (>39°C), weight loss, or fatigue (≥2 Common Terminology Criteria for Adverse Events lymphoma score for B-symptoms).

Edema, anasarca, ascites, or pleural effusion.

Hemoglobin: <12 g/dL in males, <11 g/dL in females.

§

Thrombocytopenia (PLT <100 k/μL) or thrombocytosis (PLT >350 k/μL).

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