Multivariate analysis for CIR, RFS, and OS
| Characteristic . | HR (95% CI) . | P . |
|---|---|---|
| CIR | ||
| MRD status (negative vs positive) | 0.50 (0.32-0.79) | .003 |
| Response (CR vs CRi/MLFS) | 0.45 (0.28-0.73) | .001 |
| Log of platelets | 0.74 (0.59-0.94) | .01 |
| HSCT after salvage therapy (time-dependent) | 0.20 (0.11-0.35) | <.001 |
| RFS | ||
| MRD status (negative vs positive) | 0.62 (0.41-0.93) | .02 |
| Response (CR vs CRi/MLFS) | 0.46 (0.30-0.71) | <.001 |
| Log of platelets | 0.77 (0.63-0.96) | .02 |
| HSCT after salvage therapy (time-dependent) | 0.25 (0.15-0.41) | .02 |
| OS | ||
| Cytogenetics (diploid vs others) | 0.58 (0.38-0.88) | .01 |
| HSCT after salvage therapy (time-dependent) | 0.28 (0.18-0.46) | <.001 |
| Characteristic . | HR (95% CI) . | P . |
|---|---|---|
| CIR | ||
| MRD status (negative vs positive) | 0.50 (0.32-0.79) | .003 |
| Response (CR vs CRi/MLFS) | 0.45 (0.28-0.73) | .001 |
| Log of platelets | 0.74 (0.59-0.94) | .01 |
| HSCT after salvage therapy (time-dependent) | 0.20 (0.11-0.35) | <.001 |
| RFS | ||
| MRD status (negative vs positive) | 0.62 (0.41-0.93) | .02 |
| Response (CR vs CRi/MLFS) | 0.46 (0.30-0.71) | <.001 |
| Log of platelets | 0.77 (0.63-0.96) | .02 |
| HSCT after salvage therapy (time-dependent) | 0.25 (0.15-0.41) | .02 |
| OS | ||
| Cytogenetics (diploid vs others) | 0.58 (0.38-0.88) | .01 |
| HSCT after salvage therapy (time-dependent) | 0.28 (0.18-0.46) | <.001 |
Variables included in multivariate analysis were: age, white blood cell count, platelet count, hemoglobin, bone marrow blast percentage, cytogenetics (diploid vs others), response to first induction (relapsed with first remission duration ≥1 year vs relapsed with first remission duration <1 year or refractory), prior HSCT, HSCT after salvage therapy (as time-dependent variable), hematologic response (CR vs CRi/MLFS), and MRD response (negative vs positive).