Table 1.

2016 WHO classification of mature, aggressive TCLs

PTCL-NOS 
Nodal lymphomas of TFH-cell origin, including AITL 
ALCL, ALK+ and ALK 
ATLL: acute and lymphomatous 
Extranodal T-NK-cell lymphoma, nasal type 
Intestinal TCL: EATL and monomorphic epitheliotropic intestinal TCL 
Hepatosplenic TCL 
Primary cutaneous CD8+ aggressive epidermotropic cytotoxic TCL 
Breast implant–associated ALCL: extended disease beyond the capsule (stages II- IV) 
PTCL-NOS 
Nodal lymphomas of TFH-cell origin, including AITL 
ALCL, ALK+ and ALK 
ATLL: acute and lymphomatous 
Extranodal T-NK-cell lymphoma, nasal type 
Intestinal TCL: EATL and monomorphic epitheliotropic intestinal TCL 
Hepatosplenic TCL 
Primary cutaneous CD8+ aggressive epidermotropic cytotoxic TCL 
Breast implant–associated ALCL: extended disease beyond the capsule (stages II- IV) 

ATLL, adult T-cell leukemia/lymphoma; EATL, enteropathy-associated TCL; MEITL, monomorphic epitheliotropic intestinal TCL.

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