Main clinical and biological characteristics of patients with SCD and controls
| . | Controls (n = 9) . | Steady state (n = 12) . | VOC (n = 12) . | ACS (n = 12) . | Non-ACS (n = 6) . |
|---|---|---|---|---|---|
| Age, y | 12.4 (7.9-15.6) | 10.1 (7.9-14.2) | 11.9 (9.6-14.5) | 9.7 (7.2-11.0) | 8.6 (6.1-11.5) |
| Female sex, % | 67 | 58 | 33 | 33 | 33 |
| SCD type (Hb SS/Sβ0/SC), n | — | 10/1/1 | 10/1/1 | 12/0/0 | 6/0/0 |
| Hydroxyurea, % | — | 42 | 75 | 33 | 50 |
| Transfusion program, % | — | 42 | 0 | 8 | 0 |
| Hb level, g/dL | 11.7 (11.3-12.1) | 8.8 (8.2-10.3) | 8.3 (7.6-8.8) | 7.1 (6.0-7.8) | 7.6 (7.0-7.8) |
| White blood cells, × 109/L | 4.7 (3.8-5.1) | 7.2 (5.6-8.7) | 10.4 (8.2-12.5) | 21.1 (16.0-23.1) | 12.6 (10.6-22.3) |
| Neutrophils, × 109/L | 2.5 (1.7-3.1) | 2.8 (2.5-3.5) | 5.3 (3.8-8.5) | 14.0 (9.5-16.3) | 7.7 (4.9-14.9) |
| Platelets, × 109/L | 283 (233-304) | 371 (272-395) | 306 (169-378) | 215 (175-352) | 430 (330-495) |
| CRP level, mg/L | — | — | 22 (15-42) | 149 (134-187) | 41 (21-62) |
| Interval between first symptoms and sample collection, d | — | — | 1 (1-2) | 2.5 (2-3) | 2 (1-2) |
| Golden sputum, % | — | — | — | 100 | 0 |
| Mechanical ventilation (noninvasive/invasive), % | — | — | 0 | 100 (75/25) | 0 |
| Duration of hospital stay, d | — | — | 6 (6-8) | 13 (10-16) | 6 (4-8) |
| Death, % | — | — | 0 | 0 | 0 |
| . | Controls (n = 9) . | Steady state (n = 12) . | VOC (n = 12) . | ACS (n = 12) . | Non-ACS (n = 6) . |
|---|---|---|---|---|---|
| Age, y | 12.4 (7.9-15.6) | 10.1 (7.9-14.2) | 11.9 (9.6-14.5) | 9.7 (7.2-11.0) | 8.6 (6.1-11.5) |
| Female sex, % | 67 | 58 | 33 | 33 | 33 |
| SCD type (Hb SS/Sβ0/SC), n | — | 10/1/1 | 10/1/1 | 12/0/0 | 6/0/0 |
| Hydroxyurea, % | — | 42 | 75 | 33 | 50 |
| Transfusion program, % | — | 42 | 0 | 8 | 0 |
| Hb level, g/dL | 11.7 (11.3-12.1) | 8.8 (8.2-10.3) | 8.3 (7.6-8.8) | 7.1 (6.0-7.8) | 7.6 (7.0-7.8) |
| White blood cells, × 109/L | 4.7 (3.8-5.1) | 7.2 (5.6-8.7) | 10.4 (8.2-12.5) | 21.1 (16.0-23.1) | 12.6 (10.6-22.3) |
| Neutrophils, × 109/L | 2.5 (1.7-3.1) | 2.8 (2.5-3.5) | 5.3 (3.8-8.5) | 14.0 (9.5-16.3) | 7.7 (4.9-14.9) |
| Platelets, × 109/L | 283 (233-304) | 371 (272-395) | 306 (169-378) | 215 (175-352) | 430 (330-495) |
| CRP level, mg/L | — | — | 22 (15-42) | 149 (134-187) | 41 (21-62) |
| Interval between first symptoms and sample collection, d | — | — | 1 (1-2) | 2.5 (2-3) | 2 (1-2) |
| Golden sputum, % | — | — | — | 100 | 0 |
| Mechanical ventilation (noninvasive/invasive), % | — | — | 0 | 100 (75/25) | 0 |
| Duration of hospital stay, d | — | — | 6 (6-8) | 13 (10-16) | 6 (4-8) |
| Death, % | — | — | 0 | 0 | 0 |
Data are median (interquartile range [IQR]) unless otherwise indicated.
CRP, C-reactive protein.