Neonatal complications
| Case n (mother n) . | Gestation at Tpo-RA initiation, wk (treatment duration during pregnancy, wk) . | Type of event in neonate . | Outcome (intervention) . | Causal relationship with Tpo-RA exposure in mother (yes or no)/comment . |
|---|---|---|---|---|
| 1 (1) | 36 (4) | Neonatal thrombocytopenia; platelet count, 6 × 109/L | Recovery (IV immunoglobulin + platelet transfusion) | No |
| 2 (1) | 36 (2) | Neonatal thrombocytopenia; platelet count, 8 × 109/L | Recovery (no treatment) | No |
| 3* (1) | 36 (2) | Neonatal thrombocytopenia; platelet count, 34 × 109/L | Recovery (IV immunoglobulin + platelet transfusion) | No |
| 4 (4) | 33 (7) | Neonatal thrombocytopenia; platelet count, 20 × 109/L | Recovery (IV immunoglobulin) | No |
| 5 (11) | 32 (1) | Neonatal thrombocytopenia; platelet count, 4 × 109/L | Recovery (IV immunoglobulin + platelet transfusion) | No |
| 6 (13) | 36 (1) | Neonatal thrombocytopenia; platelet count, 20 × 109/L | Recovery (IV immunoglobulin) | |
| 7 (9) | 36 (1) | Trisomy 8 (undetected preterm) | Died on day 7 | No/only 1-wk exposure to romiplostim in preparation for delivery |
| 8 (14) | 37 (1) | Pulmonary artery stenosis diagnosed during pregnancy | Favorable outcome after surgery at 2 wk of life | No/only 1-wk exposure to eltrombopag in preparation for delivery |
| 9 (8) | 30 (4) | Grade 1 intraventricular hemorrhage at birth (cranial ultrasound) | Favorable outcome without any sequela (no intervention) | Very unlikely, prematurity, favorable outcome |
| 10 (8) | 30 (4) | Neonatal thrombocytosis; platelet count, 555 × 109/L | Persistent thrombocytosis for few wk (breastfeeding on eltrombopag) | Possible |
| Case n (mother n) . | Gestation at Tpo-RA initiation, wk (treatment duration during pregnancy, wk) . | Type of event in neonate . | Outcome (intervention) . | Causal relationship with Tpo-RA exposure in mother (yes or no)/comment . |
|---|---|---|---|---|
| 1 (1) | 36 (4) | Neonatal thrombocytopenia; platelet count, 6 × 109/L | Recovery (IV immunoglobulin + platelet transfusion) | No |
| 2 (1) | 36 (2) | Neonatal thrombocytopenia; platelet count, 8 × 109/L | Recovery (no treatment) | No |
| 3* (1) | 36 (2) | Neonatal thrombocytopenia; platelet count, 34 × 109/L | Recovery (IV immunoglobulin + platelet transfusion) | No |
| 4 (4) | 33 (7) | Neonatal thrombocytopenia; platelet count, 20 × 109/L | Recovery (IV immunoglobulin) | No |
| 5 (11) | 32 (1) | Neonatal thrombocytopenia; platelet count, 4 × 109/L | Recovery (IV immunoglobulin + platelet transfusion) | No |
| 6 (13) | 36 (1) | Neonatal thrombocytopenia; platelet count, 20 × 109/L | Recovery (IV immunoglobulin) | |
| 7 (9) | 36 (1) | Trisomy 8 (undetected preterm) | Died on day 7 | No/only 1-wk exposure to romiplostim in preparation for delivery |
| 8 (14) | 37 (1) | Pulmonary artery stenosis diagnosed during pregnancy | Favorable outcome after surgery at 2 wk of life | No/only 1-wk exposure to eltrombopag in preparation for delivery |
| 9 (8) | 30 (4) | Grade 1 intraventricular hemorrhage at birth (cranial ultrasound) | Favorable outcome without any sequela (no intervention) | Very unlikely, prematurity, favorable outcome |
| 10 (8) | 30 (4) | Neonatal thrombocytosis; platelet count, 555 × 109/L | Persistent thrombocytosis for few wk (breastfeeding on eltrombopag) | Possible |
Twin of case 2.