Definition of molecular responses by peripheral blood real time quantitative polymerase chain reaction
| Deep molecular response levels . | Definition . |
|---|---|
| MR4 | BCR-ABL1 IS ratio ≤0.01% or undetectable transcripts with ≥10 000 copies of ABL1 or ≥24 000 copies of GUS |
| MR4.5 | BCR-ABL1 IS ratio ≤0.0032% or undetectable transcripts with ≥32 000 copies of ABL1 or ≥77 000 copies of GUS |
| MR5 | BCR-ABL1 IS ratio ≤0.001% or undetectable transcripts with ≥100 000 copies of ABL1 or ≥240 000 copies of GUS |
| Deep molecular response levels . | Definition . |
|---|---|
| MR4 | BCR-ABL1 IS ratio ≤0.01% or undetectable transcripts with ≥10 000 copies of ABL1 or ≥24 000 copies of GUS |
| MR4.5 | BCR-ABL1 IS ratio ≤0.0032% or undetectable transcripts with ≥32 000 copies of ABL1 or ≥77 000 copies of GUS |
| MR5 | BCR-ABL1 IS ratio ≤0.001% or undetectable transcripts with ≥100 000 copies of ABL1 or ≥240 000 copies of GUS |
IS, internationally standardized; MR4, 4-log molecular response; MR4.5, 4.5-log molecular response; MR5, 5-log molecular response.