Table 2.

Mechanisms responsible for the inadequate immune response in lymphoma

Mechanisms 
• Loss of MHC expression on malignant B cells 
• Increased expression of immunosuppressive ligands on lymphoma cells 
• Suppressive immune cell populations in the TME 
• Secreted cytokines that promote immune exhaustion or suppression 
Mechanisms 
• Loss of MHC expression on malignant B cells 
• Increased expression of immunosuppressive ligands on lymphoma cells 
• Suppressive immune cell populations in the TME 
• Secreted cytokines that promote immune exhaustion or suppression 
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