Mechanisms responsible for the inadequate immune response in lymphoma
| Mechanisms |
| • Loss of MHC expression on malignant B cells |
| • Increased expression of immunosuppressive ligands on lymphoma cells |
| • Suppressive immune cell populations in the TME |
| • Secreted cytokines that promote immune exhaustion or suppression |
| Mechanisms |
| • Loss of MHC expression on malignant B cells |
| • Increased expression of immunosuppressive ligands on lymphoma cells |
| • Suppressive immune cell populations in the TME |
| • Secreted cytokines that promote immune exhaustion or suppression |