Past medical history
| Age . | Clinical findings . |
|---|---|
| Birth | Extensive rash, resolves over 1 y |
| 12 y | Stopped growing |
| 14 y | Growth hormone deficiency diagnosed, frequent otitis externa |
| 20 y | Vulvar lesions; biopsy proves LCH, also axillary rash; never had menarche; hypogonadism |
| 23 y | Diabetes insipidus |
| 25 y | Treated with radiotherapy to pituitary, vinblastine/prednisone |
| 26 y | Recurrent skin LCH; reinduction with vinblastine/prednisone, then 6MP/Mtx for 1 y |
| 32 y | Chronic bone pain, bone scan suggesting lesions, biopsy inconclusive |
| 33 y | Hormone supplementation required for pregnancy |
| Age . | Clinical findings . |
|---|---|
| Birth | Extensive rash, resolves over 1 y |
| 12 y | Stopped growing |
| 14 y | Growth hormone deficiency diagnosed, frequent otitis externa |
| 20 y | Vulvar lesions; biopsy proves LCH, also axillary rash; never had menarche; hypogonadism |
| 23 y | Diabetes insipidus |
| 25 y | Treated with radiotherapy to pituitary, vinblastine/prednisone |
| 26 y | Recurrent skin LCH; reinduction with vinblastine/prednisone, then 6MP/Mtx for 1 y |
| 32 y | Chronic bone pain, bone scan suggesting lesions, biopsy inconclusive |
| 33 y | Hormone supplementation required for pregnancy |
6MP/Mtx, 6-mercaptopurine and methotrexate.