Table 2. Large RCTs of prophylactic vs... | American Society of Hematology

Table 2.

Large RCTs of prophylactic vs therapeutic platelet transfusion

Study/Year	Prophylactic strategy 10 × 10³/µL				Therapeutic strategy				P†
	No. of patients	Bleeding grade,* %			No. of patients	Bleeding grade,* %
	No. of patients	≥2	3	4	No. of patients	≥2	3	4
Wandt et al¹⁸/2012	194	19	3	4	197	42	7	14	<.0001
Stanworth et al¹⁹/2013	299	43	0.3	0	301	50	1.3	0.7	.06**

Study/Year	Prophylactic strategy 10 × 10³/µL				Therapeutic strategy				P†
	No. of patients	Bleeding grade,* %			No. of patients	Bleeding grade,* %
	No. of patients	≥2	3	4	No. of patients	≥2	3	4
Wandt et al¹⁸/2012	194	19	3	4	197	42	7	14	<.0001
Stanworth et al¹⁹/2013	299	43	0.3	0	301	50	1.3	0.7	.06**

WHO bleeding grading system.¹

P value for primary end point WHO grade 2 or higher bleeding.

P value for inferiority.