Currently identified acute myeloid leukemia antigens for immunotherapeutic targeting under preclinical or clinical study
| Target . | Frequency in AML . | Normal tissue expression . | Selected references . |
|---|---|---|---|
| CD7 | 10%-35% | Mature T cells, thymocytes, NK cells | 42 |
| CD13 | 75%-95% | Granulocytes, monocytes, mast cells, osteoclasts | 43 |
| CD33 | 75%-95% | Hematopoietic progenitor cells, basophils, granulocytes, mast cells, monocytes, Kupffer cells | 42 |
| CD38 | 43% | Plasma cells, hematopoietic progenitor cells, T cells, NK cells, B cells | 12 |
| CD44v6 | 64% | Keratinocytes | 44 |
| CD70 | 95% | B cells, T cells, dendritic cells | 45 |
| FLT3 (CD135) | 50% | Hematopoietic stem cells, neurons, testis | 46 |
| CD123 | 97% | Myeloid progenitors, plasmacytic dendritic cells, eosinophils, endothelial cells | 42 |
| Lewis Y (CD174) | 46% | Hematopoietic progenitor cells, intestinal epithelial cells | 47 |
| CD244 | 95% | NK cells, T cells, monocytes, basophils, eosinophils, spleen | 42 |
| TIM3 (CD366) | 85% | T cells, lung tissue | 42 |
| CLL-1 (CLEC12A, CD371) | 80% | Granulocytes, monocytes | 30,31 |
| Folate receptor B | 70% | Myeloid cells | 48 |
| NKG2DL | 70% | T-regulatory cells, endothelial cells | 49 |
| Target . | Frequency in AML . | Normal tissue expression . | Selected references . |
|---|---|---|---|
| CD7 | 10%-35% | Mature T cells, thymocytes, NK cells | 42 |
| CD13 | 75%-95% | Granulocytes, monocytes, mast cells, osteoclasts | 43 |
| CD33 | 75%-95% | Hematopoietic progenitor cells, basophils, granulocytes, mast cells, monocytes, Kupffer cells | 42 |
| CD38 | 43% | Plasma cells, hematopoietic progenitor cells, T cells, NK cells, B cells | 12 |
| CD44v6 | 64% | Keratinocytes | 44 |
| CD70 | 95% | B cells, T cells, dendritic cells | 45 |
| FLT3 (CD135) | 50% | Hematopoietic stem cells, neurons, testis | 46 |
| CD123 | 97% | Myeloid progenitors, plasmacytic dendritic cells, eosinophils, endothelial cells | 42 |
| Lewis Y (CD174) | 46% | Hematopoietic progenitor cells, intestinal epithelial cells | 47 |
| CD244 | 95% | NK cells, T cells, monocytes, basophils, eosinophils, spleen | 42 |
| TIM3 (CD366) | 85% | T cells, lung tissue | 42 |
| CLL-1 (CLEC12A, CD371) | 80% | Granulocytes, monocytes | 30,31 |
| Folate receptor B | 70% | Myeloid cells | 48 |
| NKG2DL | 70% | T-regulatory cells, endothelial cells | 49 |
NK, natural killer; T-ALL, T-cell acute lymphoblastic leukemia; T-LL, T-cell lymphoblastic lymphoma.