Acute and chronic conditions with AIP
| A. Acute signs and symptoms during AIP attack . | Frequency14,15 . |
|---|---|
| Abdominal pain | 74%–92% |
| Dark urine | 81% |
| Nausea and vomiting | 73%–85% |
| Insomnia, fatigue, weakness | 70%–80% |
| Musculoskeletal and other pain | 72% |
| Constipation | 60%–70% |
| Anxiety, depression, headache, trouble concentrating | 50%–60% |
| Hypertension, tachycardia, diaphoresis, numbness, tremulousness | 40%–60% |
| Fever, chills | 18%–33% |
| Diarrhea, heartburn, dysphoria | 20%–30% |
| Seizures | 9 |
| A. Acute signs and symptoms during AIP attack . | Frequency14,15 . |
|---|---|
| Abdominal pain | 74%–92% |
| Dark urine | 81% |
| Nausea and vomiting | 73%–85% |
| Insomnia, fatigue, weakness | 70%–80% |
| Musculoskeletal and other pain | 72% |
| Constipation | 60%–70% |
| Anxiety, depression, headache, trouble concentrating | 50%–60% |
| Hypertension, tachycardia, diaphoresis, numbness, tremulousness | 40%–60% |
| Fever, chills | 18%–33% |
| Diarrhea, heartburn, dysphoria | 20%–30% |
| Seizures | 9 |
| B. Chronic conditions and symptoms between acute attacks in patients with long-standing, recurrent AIP episodes . | Prevalence in symptomatic AIP14-16 . | Prevalence in asymptomatic HMBS carriers16 . |
|---|---|---|
| Pain syndrome, neuropathy | 43%–100% | 17%–30% |
| Psychiatric symptoms | 22%–82% | 19% |
| Hypertension | 43%–73% | 26% |
| Chronic kidney disease | 29%–64% | 13% |
| Seizures | 9%–46% | 0% |
| Dark urine | 5% | – |
| Insomnia, fatigue, weakness | 10%–20% | – |
| Nausea | 20% | – |
| Constipation | 10% | – |
| Hepatocellular carcinoma | 1%–9% | 1.9% |
| B. Chronic conditions and symptoms between acute attacks in patients with long-standing, recurrent AIP episodes . | Prevalence in symptomatic AIP14-16 . | Prevalence in asymptomatic HMBS carriers16 . |
|---|---|---|
| Pain syndrome, neuropathy | 43%–100% | 17%–30% |
| Psychiatric symptoms | 22%–82% | 19% |
| Hypertension | 43%–73% | 26% |
| Chronic kidney disease | 29%–64% | 13% |
| Seizures | 9%–46% | 0% |
| Dark urine | 5% | – |
| Insomnia, fatigue, weakness | 10%–20% | – |
| Nausea | 20% | – |
| Constipation | 10% | – |
| Hepatocellular carcinoma | 1%–9% | 1.9% |
A, incidence of symptoms and signs during an acute neurovisceral attack. B, prevalence of chronic signs and symptoms between attacks among more severely affected patients with AIP in the fourth decade of life and with multiple yearly attacks, compared with asymptomatic HMBS mutation carriers.
Adapted from references 14-16.