Criteria for TMA in patients with MIS-C, minimal COVID-19, and severe COVID-19
| ID . | Age, y . | Other conditions . | Elevated LDH . | Schistocytes . | Low platelets . | Anemia . | HTN . | Protein in urine . | Elevated sC5b9 . | Met criteria for TMA? . | No. of criterion . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Minimal COVID-19 | |||||||||||
| 13 | 4 | Sickle cell disease | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 5 | ||
| 38 | 17 | Obesity, asthma | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 5 | ||
| Summary: fraction (%) | 2/2 (100) | 1/2 (50) | 2/2 (100) | 1/2 (50) | 2/2 (100) | 1/2 (50) | 1/2 (50) | 2/2 (100) | |||
| Severe COVID-19 | |||||||||||
| 10 | 10 | Panhypopituitarism | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 6 | |
| 33 | 15 | Obesity, PCOS | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 5 | ||
| 37 | 15 | Obesity | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 6 | |
| 4 | 18 | Obesity, hypertension, diabetes mellitus | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 7 |
| Summary: fraction (%) | 4/4 (100) | 4/4 (100) | 2/4 (67) | 4/4 (100) | 3/4 (75) | 3/4 (75) | 4/4 (100) | 4/4 (100) | |||
| MIS-C | |||||||||||
| 19 | 5 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 6 | |
| 22 | 6 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 6 | |
| 18 | 6 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 7 |
| 24 | 7 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 6 | |
| 29 | 8 | Asthma | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 5 | ||
| 44 | 8 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 5 | ||
| 55 | 8 | Precocious puberty | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 6 | |
| 28 | 9 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 5 | ||
| 50 | 9 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 7 |
| 48 | 11 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 5 | ||
| 26 | 13 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 5 | ||
| 27 | 14 | Previously healthy | ✓ | ✓ | ✓ | ✓ | No | 4 | |||
| 51 | 17 | Asthma | ✓ | ✓ | ✓ | ✓ | No | 4 | |||
| Summary: fraction (%) | 8/13(61) | 12/13 (92) | 8/13(61) | 12/13 (92) | 10/13 (76) | 9/13 (69) | 12/13 (92) | 11/13 (85) | |||
| ID . | Age, y . | Other conditions . | Elevated LDH . | Schistocytes . | Low platelets . | Anemia . | HTN . | Protein in urine . | Elevated sC5b9 . | Met criteria for TMA? . | No. of criterion . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Minimal COVID-19 | |||||||||||
| 13 | 4 | Sickle cell disease | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 5 | ||
| 38 | 17 | Obesity, asthma | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 5 | ||
| Summary: fraction (%) | 2/2 (100) | 1/2 (50) | 2/2 (100) | 1/2 (50) | 2/2 (100) | 1/2 (50) | 1/2 (50) | 2/2 (100) | |||
| Severe COVID-19 | |||||||||||
| 10 | 10 | Panhypopituitarism | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 6 | |
| 33 | 15 | Obesity, PCOS | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 5 | ||
| 37 | 15 | Obesity | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 6 | |
| 4 | 18 | Obesity, hypertension, diabetes mellitus | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 7 |
| Summary: fraction (%) | 4/4 (100) | 4/4 (100) | 2/4 (67) | 4/4 (100) | 3/4 (75) | 3/4 (75) | 4/4 (100) | 4/4 (100) | |||
| MIS-C | |||||||||||
| 19 | 5 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 6 | |
| 22 | 6 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 6 | |
| 18 | 6 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 7 |
| 24 | 7 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 6 | |
| 29 | 8 | Asthma | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 5 | ||
| 44 | 8 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 5 | ||
| 55 | 8 | Precocious puberty | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 6 | |
| 28 | 9 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 5 | ||
| 50 | 9 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 7 |
| 48 | 11 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 5 | ||
| 26 | 13 | Previously healthy | ✓ | ✓ | ✓ | ✓ | ✓ | Yes | 5 | ||
| 27 | 14 | Previously healthy | ✓ | ✓ | ✓ | ✓ | No | 4 | |||
| 51 | 17 | Asthma | ✓ | ✓ | ✓ | ✓ | No | 4 | |||
| Summary: fraction (%) | 8/13(61) | 12/13 (92) | 8/13(61) | 12/13 (92) | 10/13 (76) | 9/13 (69) | 12/13 (92) | 11/13 (85) | |||
Criteria for TMA as defined by Gloude et al.27 Meeting at least 5 of the 7 criteria are required to meet definition. Protein in urine defined as random urine protein measurement ≥30 mg/dL or urine protein/creatinine ratio ≥2 mg/mg. Hypertension defined as >99th percentile for age, height, and sex. Check marks indicate that the criterion was met; blank spaces indicate that the criterion was not met.
B-ALL, B-cell acute lymphoblastic leukemia; HTN, hypertension; PCOS, polycystic ovarian syndrome.