Distribution of clinical syndromes and outcomes among case patients admitted during the neonatal period
| Syndrome . | G6PD normal boys and girls (n = 526) . | G6PD c.202T heterozygous girls (n = 88) . | P . | G6PD c.202T homozygous girls and hemizygous boys (n = 134) . | P . |
|---|---|---|---|---|---|
| Clinical, laboratory, and demographic features | |||||
| Clinical jaundice, n (%) | 157 (29.9) | 40 (45.5) | .004 | 81 (60.5) | <.0001 |
| Bacteremia,* n (%) | 34 (6.5) | 9 (10.2) | .20 | 7 (5.2) | .59 |
| Mean Hb level (95% CI), g/L | 146 (143-149) | 143 (136-150) | .49 | 138 (133-143) | .0086 |
| Anemia (Hb <110 g/L), n/N (%) | 63/512 (12.3) | 13/85 (15.3) | .44 | 19/127 (15.0) | .42 |
| Severe anemia (Hb <80 g/L), n/N (%) | 14/512 (2.7) | 1/85 (1.2) | .40 | 2/127 (1.6) | .45 |
| Median bilirubin† (IQR), μmol/L | 82.5 (37-191) | 223 (66-319) | .0001 | 239 (96-390) | <.0001 |
| Mean Hb level in those with jaundice (95% CI), g/L | 148 (142-153) | 149 (139-159) | .82 | 141 (134-147) | .12 |
| Median weight overall (IQR), kg | 2.7 (2.1-3.2) | 2.8 (2.2-3.1) | .80 | 2.7 (2.0-3.2) | .92 |
| Median weight in those with jaundice (IQR), kg | 2.7 (2.2-3.1) | 2.7 (3.4-3.0) | .91 | 2.8 (2.4-3.2) | .12 |
| Median age (IQR), d | 2 (0-9) | 4 (0-9) | .23 | 4 (1-7) | .60 |
| Median age in those with jaundice (IQR), d | 5 (2-8) | 4.5 (3-7.5) | .71 | 5 (3-7) | .97 |
| Outcome | |||||
| Median duration of admission (IQR), d | 5 (3-8) | 6 (3-8.5) | .08 | 6 (3-10) | .036 |
| Transfused, n (%) | 25 (4.8) | 11 (12.5) | .004 | 28 (20.9) | <.0001 |
| Died, n (%) | 118 (22.4) | 15 (17.1) | .26 | 32 (23.9) | .72 |
| Syndrome . | G6PD normal boys and girls (n = 526) . | G6PD c.202T heterozygous girls (n = 88) . | P . | G6PD c.202T homozygous girls and hemizygous boys (n = 134) . | P . |
|---|---|---|---|---|---|
| Clinical, laboratory, and demographic features | |||||
| Clinical jaundice, n (%) | 157 (29.9) | 40 (45.5) | .004 | 81 (60.5) | <.0001 |
| Bacteremia,* n (%) | 34 (6.5) | 9 (10.2) | .20 | 7 (5.2) | .59 |
| Mean Hb level (95% CI), g/L | 146 (143-149) | 143 (136-150) | .49 | 138 (133-143) | .0086 |
| Anemia (Hb <110 g/L), n/N (%) | 63/512 (12.3) | 13/85 (15.3) | .44 | 19/127 (15.0) | .42 |
| Severe anemia (Hb <80 g/L), n/N (%) | 14/512 (2.7) | 1/85 (1.2) | .40 | 2/127 (1.6) | .45 |
| Median bilirubin† (IQR), μmol/L | 82.5 (37-191) | 223 (66-319) | .0001 | 239 (96-390) | <.0001 |
| Mean Hb level in those with jaundice (95% CI), g/L | 148 (142-153) | 149 (139-159) | .82 | 141 (134-147) | .12 |
| Median weight overall (IQR), kg | 2.7 (2.1-3.2) | 2.8 (2.2-3.1) | .80 | 2.7 (2.0-3.2) | .92 |
| Median weight in those with jaundice (IQR), kg | 2.7 (2.2-3.1) | 2.7 (3.4-3.0) | .91 | 2.8 (2.4-3.2) | .12 |
| Median age (IQR), d | 2 (0-9) | 4 (0-9) | .23 | 4 (1-7) | .60 |
| Median age in those with jaundice (IQR), d | 5 (2-8) | 4.5 (3-7.5) | .71 | 5 (3-7) | .97 |
| Outcome | |||||
| Median duration of admission (IQR), d | 5 (3-8) | 6 (3-8.5) | .08 | 6 (3-10) | .036 |
| Transfused, n (%) | 25 (4.8) | 11 (12.5) | .004 | 28 (20.9) | <.0001 |
| Died, n (%) | 118 (22.4) | 15 (17.1) | .26 | 32 (23.9) | .72 |
Bacteremia was caused by the following organisms (n): Acinetobacter spp (4), Aeromonas spp (1), Enterobacter spp (8), Escherichia coli (6), Haemophilus influenzae (1), Klebsiella pneumoniae (2), Pseudomonas aeruginosa (3), Salmonella spp (3), Staphylococcus aureus (5), β-hemolytic Streptococcus (7), Streptococcus pneumoniae (7), Vibrio cholera (3). No independent association was seen between sex and any parameter individually.
Plasma bilirubin levels at admission in children with visible jaundice. Denominators are shown in cases where data were missing.