Clinical and laboratory characteristics of case patients
| Characteristic . | G6PD normal boys and girls . | G6PD c.202T heterozygous girls . | P . | G6PD c.202T homozygous girls and hemizygous boys . | P . |
|---|---|---|---|---|---|
| All admissions, n (%) | 5130 (75.1) | 809 (11.9) | n/a | 890 (13.0) | n/a |
| Median age (IQR), mo | 17.2 (6.9-35.8) | 16.0 (6.9-32.5) | .13 | 14.6 (5.0-33.5) | .0008 |
| Mean WAZ (95% CI) | −1.65 (−1.70 to 1.62) | −1.65 (−1.76 to 1.55) | .93 | −1.73 (−1.83 to 1.63) | .18 |
| Mean HAZ (95% CI) | −1.38 (−1.42 to 1.33) | −1.24 (−1.35 to 1.13) | .026 | −1.43 (−1.53 to 1.33) | .37 |
| Mean Hb level (95% CI), g/L | 94.3 (93.4-95.1) | 91.5 (89.3-93.6) | .017 | 93.6 (91.6-95.6) | .53 |
| Mean MCV (95% CI), fL | 74.6 (74.3-75.0) | 76.6 (75.7-77.5) | .0001 | 77.7 (76.8-78.7) | <.0001 |
| Median WBC (IQR), ×109/L | 12.1 (8.8-17.0) | 12.6 (8.7-17.8) | .18 | 12.7 (9.0-17.8) | .86 |
| Median platelets (IQR), ×109/L | 308 (152-464) | 293 (151-459) | .18 | 314 (180-490) | .049 |
| Median bilirubin* (IQR), μmol/L | 19 (9-69) | 136 (27-223) | .26 | 110 (37-383) | .48 |
| Median parasite density† (IQR), per μL | 49 720 (3 599-224 000) | 28 399 (3 383-176 400) | .10 | 33 800 (3 770-180 120) | .24 |
| Characteristic . | G6PD normal boys and girls . | G6PD c.202T heterozygous girls . | P . | G6PD c.202T homozygous girls and hemizygous boys . | P . |
|---|---|---|---|---|---|
| All admissions, n (%) | 5130 (75.1) | 809 (11.9) | n/a | 890 (13.0) | n/a |
| Median age (IQR), mo | 17.2 (6.9-35.8) | 16.0 (6.9-32.5) | .13 | 14.6 (5.0-33.5) | .0008 |
| Mean WAZ (95% CI) | −1.65 (−1.70 to 1.62) | −1.65 (−1.76 to 1.55) | .93 | −1.73 (−1.83 to 1.63) | .18 |
| Mean HAZ (95% CI) | −1.38 (−1.42 to 1.33) | −1.24 (−1.35 to 1.13) | .026 | −1.43 (−1.53 to 1.33) | .37 |
| Mean Hb level (95% CI), g/L | 94.3 (93.4-95.1) | 91.5 (89.3-93.6) | .017 | 93.6 (91.6-95.6) | .53 |
| Mean MCV (95% CI), fL | 74.6 (74.3-75.0) | 76.6 (75.7-77.5) | .0001 | 77.7 (76.8-78.7) | <.0001 |
| Median WBC (IQR), ×109/L | 12.1 (8.8-17.0) | 12.6 (8.7-17.8) | .18 | 12.7 (9.0-17.8) | .86 |
| Median platelets (IQR), ×109/L | 308 (152-464) | 293 (151-459) | .18 | 314 (180-490) | .049 |
| Median bilirubin* (IQR), μmol/L | 19 (9-69) | 136 (27-223) | .26 | 110 (37-383) | .48 |
| Median parasite density† (IQR), per μL | 49 720 (3 599-224 000) | 28 399 (3 383-176 400) | .10 | 33 800 (3 770-180 120) | .24 |
Percentages reflect column percentages with the exception of all admissions. P values estimated by Student t, χ2, or Mann-Whitney U tests as appropriate in comparison with the G6PD normal group.
HAZ, height-for-age Z-score; IQR, interquartile range; MCV, mean cell volume; n/a, not applicable; WAZ, weight-for-age Z-score; WBC, white blood cell count.
Bilirubin levels among those with detectable jaundice.
Parasite densities among the fraction with positive blood films. No independent association was seen between sex and any parameter individually.