Validated criteria for HR and organ response
| Category . | Criteria . |
|---|---|
| HR | CR (all of the following criteria must be met):
|
| VGPR reduction of dFLC below 40 mg/L | |
| PR 50% reduction of dFLC | |
| Organ response | Kidney: a 30% reduction in 24-h urine protein excretion or a drop of proteinuria below 0.5 g per 24 h in the absence of progressive renal insufficiency, defined as a decrease in eGFR to 25% over baseline. |
| Heart (NT-proBNP based): reduction of NT-proBNP of 30% and >300 ng/L over the starting value. Baseline NT-proBNP has to be ≥650 ng/L to be measurable. | |
| Heart (BNP based): reduction of BNP of 30% and >50 ng/L over the starting value. Baseline BNP has to be ≥150 ng/L to be measurable. | |
| CHOR model | Patients are classified in 2 CHOR groups according to a score based on the HR and organ response criteria
|
| CHOR group 1, score 0-3 | |
| CHOR group 2, score 4-5 |
| Category . | Criteria . |
|---|---|
| HR | CR (all of the following criteria must be met):
|
| VGPR reduction of dFLC below 40 mg/L | |
| PR 50% reduction of dFLC | |
| Organ response | Kidney: a 30% reduction in 24-h urine protein excretion or a drop of proteinuria below 0.5 g per 24 h in the absence of progressive renal insufficiency, defined as a decrease in eGFR to 25% over baseline. |
| Heart (NT-proBNP based): reduction of NT-proBNP of 30% and >300 ng/L over the starting value. Baseline NT-proBNP has to be ≥650 ng/L to be measurable. | |
| Heart (BNP based): reduction of BNP of 30% and >50 ng/L over the starting value. Baseline BNP has to be ≥150 ng/L to be measurable. | |
| CHOR model | Patients are classified in 2 CHOR groups according to a score based on the HR and organ response criteria
|
| CHOR group 1, score 0-3 | |
| CHOR group 2, score 4-5 |
CHOR, composite hematologic/organ response model; PR, partial response.