Suggestions for TKI selection for frontline therapy based on selected comorbidities
| Comorbidity . | Preferred . | Less preferred . |
|---|---|---|
| Diabetes | Imatinib, dasatinib, bosutinib | Nilotinib |
| Pulmonary disease/pulmonary arterial hypertension | Imatinib, bosutinib, nilotinib | Dasatinib |
| Gastrointestinal issues | Nilotinib, dasatinib | Imatinib, bosutinib |
| Cardiovascular | Imatinib, bosutinib | Nilotinib, dasatinib |
| Peripheral arterial | Imatinib, bosutinib (dasatinib?) | Nilotinib |
| Liver | Imatinib, dasatinib (nilotinib?) | Bosutinib |
| Renal | Nilotinib, dasatinib | Imatinib, bosutinib |
| Comorbidity . | Preferred . | Less preferred . |
|---|---|---|
| Diabetes | Imatinib, dasatinib, bosutinib | Nilotinib |
| Pulmonary disease/pulmonary arterial hypertension | Imatinib, bosutinib, nilotinib | Dasatinib |
| Gastrointestinal issues | Nilotinib, dasatinib | Imatinib, bosutinib |
| Cardiovascular | Imatinib, bosutinib | Nilotinib, dasatinib |
| Peripheral arterial | Imatinib, bosutinib (dasatinib?) | Nilotinib |
| Liver | Imatinib, dasatinib (nilotinib?) | Bosutinib |
| Renal | Nilotinib, dasatinib | Imatinib, bosutinib |