Summary of most common treatment-emergent AEs
| . | Pacritinib, no. (%) . | |||||
|---|---|---|---|---|---|---|
| 100 mg once per d (n = 52) . | 100 mg twice per d (n = 55) . | 200 mg twice per d (n = 54) . | ||||
| Any grade . | Grade 3 to 4 . | Any grade . | Grade 3 to 4 . | Any grade . | Grade 3 to 4 . | |
| Nonhematologic AEs | ||||||
| Diarrhea | 10 (19.2) | 1 (1.9) | 12 (21.8) | 2 (3.6) | 16 (29.6) | 3 (5.6) |
| Nausea | 12 (23.1) | 0 | 11 (20.0) | 0 | 15 (27.8) | 0 |
| Fatigue | 9 (17.3) | 3 (5.8) | 13 (23.6) | 2 (3.6) | 13 (24.1) | 2 (3.7) |
| Abdominal pain | 9 (17.3) | 0 | 6 (10.9) | 2 (3.6) | 13 (24.1) | 3 (5.6) |
| Fever | 8 (15.4) | 1 (1.9) | 9 (16.4) | 1 (1.8) | 7 (13.0) | 1 (1.9) |
| Peripheral edema | 7 (13.5) | 0 | 5 (9.1) | 0 | 9 (16.7) | 1 (1.9) |
| Decreased appetite | 6 (11.5) | 0 | 4 (7.3) | 0 | 10 (18.5) | 1 (1.9) |
| Pruritis | 2 (3.8) | 0 | 10 (18.2) | 1 (1.8) | 6 (11.1) | 0 |
| Constipation | 2 (3.8) | 0 | 1 (1.8) | 0 | 10 (18.5) | 0 |
| Pneumonia | 4 (7.7) | 2 (3.8) | 2 (3.6) | 2 (3.6) | 5 (9.3) | 5 (9.3) |
| Hyperuricemia | 1 (1.9) | 1 (1.9) | 2 (3.6) | 1 (1.8) | 3 (5.6) | 3 (5.6) |
| Hyponatremia | 0 | 0 | 3 (5.5) | 3 (5.5) | 3 (5.6) | 2 (3.7) |
| Dehydration | 0 | 0 | 3 (5.5) | 3 (5.5) | 4 (7.4) | 1 (1.9) |
| Hypertension | 0 | 0 | 3 (5.5) | 3 (5.5) | 2 (3.7) | 1 (1.9) |
| Hematologic AEs | ||||||
| Thrombocytopenia* | 11 (21.2) | 10 (19.2) | 12 (21.8) | 12 (21.8) | 22 (40.7) | 18 (33.3) |
| Anemia | 5 (9.6) | 5 (9.6) | 6 (10.9) | 4 (7.3) | 13 (24.1) | 11 (20.4) |
| Neutropenia† | 3 (5.8) | 3 (5.8) | 3 (5.5) | 3 (5.5) | 3 (5.6) | 3 (5.6) |
| . | Pacritinib, no. (%) . | |||||
|---|---|---|---|---|---|---|
| 100 mg once per d (n = 52) . | 100 mg twice per d (n = 55) . | 200 mg twice per d (n = 54) . | ||||
| Any grade . | Grade 3 to 4 . | Any grade . | Grade 3 to 4 . | Any grade . | Grade 3 to 4 . | |
| Nonhematologic AEs | ||||||
| Diarrhea | 10 (19.2) | 1 (1.9) | 12 (21.8) | 2 (3.6) | 16 (29.6) | 3 (5.6) |
| Nausea | 12 (23.1) | 0 | 11 (20.0) | 0 | 15 (27.8) | 0 |
| Fatigue | 9 (17.3) | 3 (5.8) | 13 (23.6) | 2 (3.6) | 13 (24.1) | 2 (3.7) |
| Abdominal pain | 9 (17.3) | 0 | 6 (10.9) | 2 (3.6) | 13 (24.1) | 3 (5.6) |
| Fever | 8 (15.4) | 1 (1.9) | 9 (16.4) | 1 (1.8) | 7 (13.0) | 1 (1.9) |
| Peripheral edema | 7 (13.5) | 0 | 5 (9.1) | 0 | 9 (16.7) | 1 (1.9) |
| Decreased appetite | 6 (11.5) | 0 | 4 (7.3) | 0 | 10 (18.5) | 1 (1.9) |
| Pruritis | 2 (3.8) | 0 | 10 (18.2) | 1 (1.8) | 6 (11.1) | 0 |
| Constipation | 2 (3.8) | 0 | 1 (1.8) | 0 | 10 (18.5) | 0 |
| Pneumonia | 4 (7.7) | 2 (3.8) | 2 (3.6) | 2 (3.6) | 5 (9.3) | 5 (9.3) |
| Hyperuricemia | 1 (1.9) | 1 (1.9) | 2 (3.6) | 1 (1.8) | 3 (5.6) | 3 (5.6) |
| Hyponatremia | 0 | 0 | 3 (5.5) | 3 (5.5) | 3 (5.6) | 2 (3.7) |
| Dehydration | 0 | 0 | 3 (5.5) | 3 (5.5) | 4 (7.4) | 1 (1.9) |
| Hypertension | 0 | 0 | 3 (5.5) | 3 (5.5) | 2 (3.7) | 1 (1.9) |
| Hematologic AEs | ||||||
| Thrombocytopenia* | 11 (21.2) | 10 (19.2) | 12 (21.8) | 12 (21.8) | 22 (40.7) | 18 (33.3) |
| Anemia | 5 (9.6) | 5 (9.6) | 6 (10.9) | 4 (7.3) | 13 (24.1) | 11 (20.4) |
| Neutropenia† | 3 (5.8) | 3 (5.8) | 3 (5.5) | 3 (5.5) | 3 (5.6) | 3 (5.6) |