Intercrosses of Lman1 mutant mice
| Crosses . | Strain . | Genotype distribution at 3 wk, % (no. observed) . | P, χ2 . | |
|---|---|---|---|---|
| +/+ and +/− . | −/− . | |||
| Expected % | 75 | 25 | ||
| Lman1gt1/+ x Lman1gt1/+ | C57BL/6J | 83 (201) | 17 (40) | <.003 |
| Lman1cgt/+ x Lman1cgt/+ | C57BL/6J | 80 (107) | 20 (27) | >.19 |
| Lman1+/− x Lman1+/− | C57BL/6J | 83 (184) | 17 (38) | <.007 |
| Dead pups (<24 h) | C57BL/6J | 50 (11) | 50 (11) | <.007 |
| Lman1+/− x Lman1+/− | B6;129 mixed | 76 (95) | 24 (30) | >.79 |
| Crosses . | Strain . | Genotype distribution at 3 wk, % (no. observed) . | P, χ2 . | |
|---|---|---|---|---|
| +/+ and +/− . | −/− . | |||
| Expected % | 75 | 25 | ||
| Lman1gt1/+ x Lman1gt1/+ | C57BL/6J | 83 (201) | 17 (40) | <.003 |
| Lman1cgt/+ x Lman1cgt/+ | C57BL/6J | 80 (107) | 20 (27) | >.19 |
| Lman1+/− x Lman1+/− | C57BL/6J | 83 (184) | 17 (38) | <.007 |
| Dead pups (<24 h) | C57BL/6J | 50 (11) | 50 (11) | <.007 |
| Lman1+/− x Lman1+/− | B6;129 mixed | 76 (95) | 24 (30) | >.79 |
The χ2 test was based on an expected genotype ratio of 3:1, with Lman1−/− mice expected to represent 25% of the offspring from each mating, and all other genotypes cumulatively accounting for 75% of offspring.