Neuropathies with antibodies against disialylated gangliosides and MAG
| Targets . | Gangliosides GD1b, GQ1b, GT1a . | Gangliosides GD1b, GD3, GT1b, GQ1b . | MAG + SGPG or SGLPG . |
|---|---|---|---|
| Isotype | IgG | IgM | IgM |
| Kappa = lambda | Kappa > lambda | ||
| Mono/polyclonal | Polyclonal | Monoclonal | Monoclonal |
| Evolution | Acute, reversible | Chronic | Chronic |
| Syndrome | Miller Fisher | CANDA | Anti-MAG neuropathy |
| Clinical signs | Ophthalmoplegia, ataxia, areflexia | Sensory ataxia, paresthesia, hypoesthesia, areflexia | Distal demyelinating symmetric sensory and motor neuropathy, ataxia, tremor |
| Acute ataxic neuropathy | CANOMAD | ||
| Idem, no ophthalmoplegia | + ophthalmoplegia and cold agglutinin | ||
| Underlying clonal hematologic disease | No | MGUS IgM 66% | MGUS IgM 80% |
| Waldenström disease | Waldenström disease | ||
| Low-grade B-cell lymphoma | Low-grade B-cell lymphoma | ||
| Treatment | IVIG | IVIG, rituximab-based regimens | Rituximab-based regimens |
| Targets . | Gangliosides GD1b, GQ1b, GT1a . | Gangliosides GD1b, GD3, GT1b, GQ1b . | MAG + SGPG or SGLPG . |
|---|---|---|---|
| Isotype | IgG | IgM | IgM |
| Kappa = lambda | Kappa > lambda | ||
| Mono/polyclonal | Polyclonal | Monoclonal | Monoclonal |
| Evolution | Acute, reversible | Chronic | Chronic |
| Syndrome | Miller Fisher | CANDA | Anti-MAG neuropathy |
| Clinical signs | Ophthalmoplegia, ataxia, areflexia | Sensory ataxia, paresthesia, hypoesthesia, areflexia | Distal demyelinating symmetric sensory and motor neuropathy, ataxia, tremor |
| Acute ataxic neuropathy | CANOMAD | ||
| Idem, no ophthalmoplegia | + ophthalmoplegia and cold agglutinin | ||
| Underlying clonal hematologic disease | No | MGUS IgM 66% | MGUS IgM 80% |
| Waldenström disease | Waldenström disease | ||
| Low-grade B-cell lymphoma | Low-grade B-cell lymphoma | ||
| Treatment | IVIG | IVIG, rituximab-based regimens | Rituximab-based regimens |