Investigations required in the initial evaluation of gravidic TMAs
| Diagnostic parameters . | Role . |
|---|---|
| CBC (PLT, Hb, MCV), RET; LDH; bilirubin (total, indirect), haptoglobin; Coombs test; blood smear | To diagnose a TMA; MAHA with thrombocytopenia |
| Fetal ultrasound/uterine artery Doppler scan | To assess fetoplacental status |
| ALT, AST; creatinine, urinalysis, 24-h urine proteins; cardiac troponin, ECG; coagulation screening (PT, aPTT, D-dimer, fibrinogen); CRP, WBCs; autoimmune screening (aPL, ANA, ANCA); stool culture/STEC testing (if indicated) | To assess organ damage and make differential diagnosis |
| ADAMTS13 (activity and anti-ADAMTS13 antibody) | To confirm TTP clinical diagnosis |
| Diagnostic parameters . | Role . |
|---|---|
| CBC (PLT, Hb, MCV), RET; LDH; bilirubin (total, indirect), haptoglobin; Coombs test; blood smear | To diagnose a TMA; MAHA with thrombocytopenia |
| Fetal ultrasound/uterine artery Doppler scan | To assess fetoplacental status |
| ALT, AST; creatinine, urinalysis, 24-h urine proteins; cardiac troponin, ECG; coagulation screening (PT, aPTT, D-dimer, fibrinogen); CRP, WBCs; autoimmune screening (aPL, ANA, ANCA); stool culture/STEC testing (if indicated) | To assess organ damage and make differential diagnosis |
| ADAMTS13 (activity and anti-ADAMTS13 antibody) | To confirm TTP clinical diagnosis |
ANA, anti-nuclear antibody; ANCA, anti-neutrophil cytoplasmic autoantibody; aPL, anti-phospholipid antibodies (lupus anticoagulant, anticardiolipin, anti-β2-glycoprotein 1 antibodies); aPTT, activated partial thromboplastin time; ECG, electrocardiogram; PLT, platelet; RET, reticulocytes; PT, prothrombin time; STEC, Shiga toxin Escherichia coli; WBC, white blood cell.