Table 1. Clinical characteristics .... | American Society of Hematology

Table 1.

Clinical characteristics

	CHIP-mutation negative		CHIP-mutation positive			Total
	N	%	N	%	P	N	%
Total	380	63.97	214	36.03		594	100.00
Men	127	33.42	69	32.24	.769	196	33.00
Age at blood collection, y
73-75	72	18.95	29	13.55	<.001	101	17.00
75-80	205	53.95	101	47.20		306	51.52
80-85	82	21.58	47	21.96		129	21.72
85-93	21	5.53	37	17.29		58	9.76
Zygosity
MZ	155	40.79	101	47.20	.130	256	43.10
DZ	225	59.21	113	52.80		338	56.90
Tobacco consumption (pack-years)
0	146	38.42	79	36.92	.815	225	37.88
1st tertile (1-8.55)	746	20.00	40	18.69		116	19.53
2nd tertile (8.55-25)	77	20.26	46	21.50		123	20.71
3rd tertile (25+)	65	17.11	43	20.09		108	18.18
Missing	16	4.21	6	2.80		22	3.70
Dead prior to August 2018	359	94.47	210	98.13	.033	569	95.79

	CHIP-mutation negative		CHIP-mutation positive			Total
	N	%	N	%	P	N	%
Total	380	63.97	214	36.03		594	100.00
Men	127	33.42	69	32.24	.769	196	33.00
Age at blood collection, y
73-75	72	18.95	29	13.55	<.001	101	17.00
75-80	205	53.95	101	47.20		306	51.52
80-85	82	21.58	47	21.96		129	21.72
85-93	21	5.53	37	17.29		58	9.76
Zygosity
MZ	155	40.79	101	47.20	.130	256	43.10
DZ	225	59.21	113	52.80		338	56.90
Tobacco consumption (pack-years)
0	146	38.42	79	36.92	.815	225	37.88
1st tertile (1-8.55)	746	20.00	40	18.69		116	19.53
2nd tertile (8.55-25)	77	20.26	46	21.50		123	20.71
3rd tertile (25+)	65	17.11	43	20.09		108	18.18
Missing	16	4.21	6	2.80		22	3.70
Dead prior to August 2018	359	94.47	210	98.13	.033	569	95.79

We included 299 twin pairs and sequenced peripheral blood DNA from all twins. Four twins had low-quality DNA and were excluded from the study, and 594 remaining twins were included in the study. In August 2018, 96% of the cohort had died, and follow-up was available for all twins. Only 38% of the cohort never smoked; the smokers were divided into tertiles according to tobacco consumption for survival analysis.

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