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Jesús F. San Miguel
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Journal Articles

Measurable residual disease by mass spectrometry and next-generation flow to assess treatment response in myeloma

Clinical Trials & Observations Brief Report
Noemí Puig, Cristina Agulló, Teresa Contreras, María-Teresa Cedena, Joaquín Martínez-López, Albert Oriol, María-Jesús Blanchard, Rafael Ríos, María-Belén Íñigo, Anna Sureda, Sunil Lakhwani, Javier de la Rubia, Verónica González-Calle, Valentín Cabañas, Luis Palomera, José-María Moraleda, Joan Bargay, Sergio Castro, Laura Rosiñol, Joan Bladé, Jesús F. San-Miguel, Juan-José Lahuerta, Bruno Paiva, María-Victoria Mateos
Journal: Blood
Blood (2024) 144 (23): 2432–2438.
https://doi.org/10.1182/blood.2024024995
Published: 2024
Includes: Supplemental data
Journal Articles

Biological and Clinical Significance of Endogenous and Chimeric Antigen Receptor (CAR) T Cell Immune Profiling in Relapsed/Refractory Multiple Myeloma (RRMM) Patients

Bruno Paiva, Irene Manrique, Ethan G. Thompson, Timothy B. Campbell, Camila Guerrero, Nathan Martin, Larry D Anderson, Jr., Jesus G Berdeja, Sagar Lonial, Noopur Raje, Yi Lin, Philippe Moreau, Jesús F. San-Miguel, Nikhil C. Munshi, Shari Kaiser
Journal: Blood
Blood (2024) 144 (Supplement 1): 900.
https://doi.org/10.1182/blood-2024-203007
Published: 2024
Journal Articles

Early Relapse in Patients with Newly-Diagnosed Multiple Myeloma: A European Myeloma Network/Harmony Alliance Analysis Including 10843 Patients

Elias K. Mai, Andrea Manubens, Mattia D'Agostino, David A. Cairns, Alessandra Larocca, Juan José Lahuerta Palacios, Ruth Wester, Uta Bertsch, Anders Waage, Elena Zamagni, María-Victoria Mateos, Daniele Dall'Olio, Niels W.C.J. van de Donk, Graham Jackson, Serena Rocchi, Hans Salwender, Joan Bladé, Bronno van der Holt, Gastone Castellani, Katja C. Weisel, Francesca Gay, Sonja Zweegman, Michele Cavo, Jesus Maria Hernandez Rivas, Benedetto Bruno, Gordon Cook, Martin F Kaiser, Hartmut Goldschmidt, Mario Boccadoro, Jesús F. San-Miguel, Pieter Sonneveld
Journal: Blood
Blood (2024) 144 (Supplement 1): 898.
https://doi.org/10.1182/blood-2024-193310
Published: 2024
Journal Articles

Clinical Significance of Measurable Residual Disease (MRD) in Light-Chain (AL) Amyloidosis

Marta Lasa, Mario Nuvolone, Ioannis V Kostopoulos, Tomas Jelinek, Marco Basset, Paolo Milani, Margherita Massa, Foteini Theodorakakou, Ashutosh D. Wechalekar, Anastasiia Zherniakova, Rafael Ríos, Irene Romera, Maria Teresa Cedena Romero, Noemi Puig, Ramon Lecumberri Villamediana, Jesús F. San-Miguel, Roman Hajek, Giampaolo Merlini, Efstathios Kastritis, Bruno Paiva, Giovanni O. Palladini
Journal: Blood
Blood (2024) 144 (Supplement 1): 889.
https://doi.org/10.1182/blood-2024-202995
Published: 2024
Journal Articles

GEM2017Fit Phase 3 Trial in Fit Elderly Patients (Aged 65-80) with Newly Diagnosed Myeloma: Impact of Daratumumab at Induction and/or Consolidation

Maria- Victoria Mateos, Bruno Paiva, Maria Teresa Cedena Romero, Noemi Puig, Anna Sureda Balari, Albert Oriol, Enrique M Ocio, Laura Rosiñol, Yolanda González-Montes, Joan Bargay, Esther Gonzalez Garcia, Miguel Teodoro Hernández Garcia, Angel Ramirez, Alexia Suarez-Cabrera, María-Jesús Blanchard, Sebastián Garzón, Luis Felipe Casado, Valentin Cabanas Perianes, Jaime Perez de Oteyza, Mercedes Gironella, Joaquin Martínez-López, Ana-Isabel -Teruel, Pilar Delgado, Elena Prieto, Juan-Jose Lahuerta Palacios, Joan Bladé, Jesús F. San-Miguel
Journal: Blood
Blood (2024) 144 (Supplement 1): 678.
https://doi.org/10.1182/blood-2024-203170
Published: 2024
Journal Articles

An IFNγ-Mediated Immune Inflamed Microenvironment State in Multiple Myeloma with TP53 Loss That Can be Therapeutically Exploited

Marta Larrayoz, Elena Arriazu, Aintzane Zabaleta, Carmen Roncal, Ibon Tamayo, Diana Llopiz, Maddalen Jimenez, Carla Castro, Jon Celay, Carmen Vicente, Camila Guerrero, Sonia Sanz, Maria J Garcia-Barchino, Naroa Barrena, Noemi Puig, Maria Teresa Cedena Romero, Maria Jose Calasanz, Paula Rodríguez-Otero, Jesús F. San-Miguel, Mikel Hernaez, Xabier Agirre, Pablo Sarobe, Felipe Prosper, Bruno Paiva, Jose A. Martinez-Climent
Journal: Blood
Blood (2024) 144 (Supplement 1): 670.
https://doi.org/10.1182/blood-2024-194041
Published: 2024
Journal Articles

Teclistamab, Daratumumab, and Pomalidomide in Patients with Relapsed/Refractory Multiple Myeloma: Results from the Majestec-2 Cohort a and Trimm-2 Studies

Anita D'Souza, Luciano J. Costa, Jesús F. San-Miguel, Jesus G Berdeja, Daniel Morillo Giles, Cyrille Touzeau, John T McKay, Bhagirathbhai Dholaria, Thomas G Martin, Aurore Perrot, Albert Oriol, Anna Sureda Balari, Thomas Prior, Debopriya Ghosh, Lijuan Kang, Julie S Larsen, Hein Ludlage, Lien Vandenberk, Lingling Chen, Bas D Koster, Weili Sun, Rachel Kobos, Emma Searle, Jeffrey V Matous, Ajai Chari, Tobias Kampfenkel
Journal: Blood
Blood (2024) 144 (Supplement 1): 495.
https://doi.org/10.1182/blood-2024-200181
Published: 2024
Journal Articles

Reevaluating the IMWG Multiple Myeloma Complete Response Criterion in the Era of Mass Spectrometry: A Critical Analysis

Noemi Puig, Cristina Agullo, Bruno Paiva, María T Cedena, Laura Rosiñol Dachs, Teresa Contreras, Joaquín Martínez-Lopez, Albert Oriol, María-Jesús Blanchard, Rafael Rios Tamayo, Ana Maria Sureda Balari, Miguel Teodoro Hernández Garcia, Javier de la Rubia, Valentin Cabanas Perianes, Felipe De Arriba, Luis Palomera, Maria Belen Inigo Rodriguez, Veronica Gonzalez-Calle, Enrique M Ocio, Sergio Castro, Joan Bargay, Joan Bladé, Jesús F. San-Miguel, Juan-Jose Lahuerta Palacios, Maria- Victoria Mateos
Journal: Blood
Blood (2024) 144 (Supplement 1): 489.
https://doi.org/10.1182/blood-2024-210198
Published: 2024
Journal Articles

Comparative Efficacy of Ciltacabtagene Autoleucel Versus Isatuximab, Carfilzomib and Dexamethasone in the Treatment of Patients with Lenalidomide-Refractory Multiple Myeloma with 1-3 Prior Lines of Therapy Using a Matching-Adjusted Indirect Comparison

Roberto Mina, Paolo Corradini, Michele Cavo, Jesús F. San-Miguel, Leyla O. Shune, Abdullah Mohammad Khan, Surbhi Sidana, Xavier Leleu, Salomon Manier, Brea Lipe, Katja C. Weisel, Suzy van Sanden, Joris Diels, João Mendes, Seina Lee, Sandra Van Hoorenbeeck, Adrián Pons, Ana Slaughter, Nina Benachour, Carolina Lonardi, Arnab Ghosh, Nitin Patel, Erika Florendo, Joaquín Martínez-Lopez
Journal: Blood
Blood (2024) 144 (Supplement 1): 7088.
https://doi.org/10.1182/blood-2024-205189
Published: 2024
Journal Articles

Molecular Mechanisms Promoting Long-Term Cytopenia after BCMA CAR-T Therapy in Multiple Myeloma

Maria Luisa Palacios-Berraquero, Paula Rodriguez-Marquez, Maria Erendira Calleja-Cervantes, Nerea Berastegui, Aintzane Zabaleta, Leire Burgos, Diego Alignani, Patxi San-Martin, Amaia Vilas-Zornoza, Saray Rodríguez Diaz, Susana Inogés, Ascensión López-Díaz De Cerio, Sofia Huerga, Luis-Esteban Tamariz-Amador, Jose J. Rifon, Ana Alfonso Pierola, Juan J Lasarte, Bruno Paiva, Mikel Hernaez, Paula Rodríguez-Otero, Jesús F. San-Miguel, Teresa Ezponda, Juan Roberto Rodriguez-Madoz, Felipe Prosper
Journal: Blood
Blood (2024) 144 (Supplement 1): 4798.
https://doi.org/10.1182/blood-2024-207990
Published: 2024
Journal Articles

Survival Improvement of Transplant Eligible Patients with Newly Diagnosed Multiple Myeloma in Two Consecutive Randomized Phase III Trials: Long-Term Follow up of GEM05 and GEM12 Trials

Laura Rosiñol Dachs, Albert Oriol, María-Jesús Blanchard, Javier de la Rubia, Rafael Ríos, Joan Bargay, Miguel Teodoro Hernández Garcia, Valentín Cabanas Perianes, Ana López de la Guía, Estrella Carrillo-Cruz, Anna Sureda Balari, Joaquin Martínez-López, Jose Maria Arguiñano, Esther González García, Luis Felipe Casado, Josep Maria Marti Tutusaus, Cristina Encinas, Felipe De Arriba, Luis Palomera, Antonia Sampol Mayol, Yolanda González-Montes, Jordi López-Pardo, Maialen Sirvent, Maria Belen Inigo Rodriguez, Bruno Paiva, Noemi Puig, Maria Teresa Cedena Romero, Norma C. Gutierrez, Javier De la Cruz, Maria-Victoria Mateos, Jesús F. San-Miguel, Juan-Jose Lahuerta Palacios, Joan Bladé
Journal: Blood
Blood (2024) 144 (Supplement 1): 3374.
https://doi.org/10.1182/blood-2024-205453
Published: 2024
Journal Articles

Single-Cell Multiomics Data-Driven Measurable Residual Disease (MRD) Assessment Using Multidimensional Flow Cytometry (MFC) in Acute Myeloid Leukemia (AML)

Carmen Gonzalez, Catia Simoes, Leire Burgos, David Martinez-Cuadron, Sarai Sarvide, Diego Alignani, Aitziber Lopez, Yujuan Gui, Hana Komic, Tessa Schmachtel, Carmen Botella, Raimundo Garcia Boyero, Esther Perez Santaolla, Cristina Gil, Jesús Lorenzo Algarra, Maria Jose Sayas Lloris, Francisco Ibañez, Laura Torres, Isabel Cano-Ferri, Evelyn Acuña-Cruz, Olga Arce, Fredrik B. Thorén, Michael A. Rieger, Jesús F. San-Miguel, Felipe Prosper, Pau Montesinos, Bruno Paiva
Journal: Blood
Blood (2024) 144 (Supplement 1): 4328.
https://doi.org/10.1182/blood-2024-203076
Published: 2024
Journal Articles

Multiomic Characterization of Clonotypic B Cells in Patients with Monoclonal Gammopathies

Carmen Gonzalez, Camila Guerrero, Juan-José Garcés, Alejandro Medina, Noemi Puig, Maria Teresa Cedena Romero, Diego Alignani, Sarai Sarvide, Paula Aguirre-Ruiz, Jose Maria Lamo-Espinosa, Felipe Prosper, Paula Rodríguez-Otero, Jose A. Martinez-Climent, Aldo Roccaro, Antonio Sacco, Mario Nuvolone, Giovanni O. Palladini, Laura Rosiñol Dachs, Ramon García-Sanz, Joaquín Martínez-Lopez, Juan-Jose Lahuerta Palacios, Maria-Victoria Mateos, Joan Bladé, Jesús F. San-Miguel, Bruno Paiva
Journal: Blood
Blood (2024) 144 (Supplement 1): 1879.
https://doi.org/10.1182/blood-2024-201435
Published: 2024
Journal Articles

Depletion of Mature B Cells and of Normal Plasma Cells (PC) behind the Higher Incidence of Infections after Anti-BCMA VS Anti-GPRC5D Bispecific Antibodies (bsAb) in Relapsed Refractory Multiple Myeloma (RRMM)

Tomas Jelinek, David Zihala, Aintzane Zabaleta, Ioannis V Kostopoulos, Ondrej Soucek, Ondrej Venglar, Cristina Moreno, Despina Fotiou, Eva Radova, Luis-Esteban Tamariz-Amador, Foteini Theodorakakou, Ludmila Muronova, Andrea Manubens, Ourania Tsitsilonis, Tereza Popkova, Lucie Broskevicova, Jana Mihalyova, Tereza Sevcikova, Jesús F. San-Miguel, Meletios Dimopoulos, Paula Rodríguez-Otero, Jakub Radocha, Efstathios Kastritis, Bruno Paiva, Roman Hajek
Journal: Blood
Blood (2024) 144 (Supplement 1): 1934.
https://doi.org/10.1182/blood-2024-205481
Published: 2024
Journal Articles

Development and Validation of Novel Machine Learning-Based Risk Scores for Multiple Myeloma: Insights from the Harmony Alliance Big Data Platform

Adrian Mosquera Orgueira, Marta Sonia Gonzalez Perez, Mattia D'Agostino, David A. Cairns, Alessandra Larocca, Juan José Lahuerta Palacios, Ruth Wester, Uta Bertsch, Anders Waage, Elena Zamagni, Carlos Pérez Míguez, Niels W.C.J. Van De Donk, Graham Jackson, Davide Crucitti, Hans Salwender, Daniele Dall'Olio, Gastone Castellani, Manuel Piñeiro Fiel, Sara Bringhen, Sonja Zweegman, Michele Cavo, Jesus Maria Hernandez Rivas, Benedetto Bruno, Gordon Cook, Martin F Kaiser, Hartmut Goldschmidt, Pieter Sonneveld, Jesús F. San-Miguel, Mario Boccadoro, Maria- Victoria Mateos
Journal: Blood
Blood (2024) 144 (Supplement 1): 2226.
https://doi.org/10.1182/blood-2024-201448
Published: 2024
Journal Articles

Isatuximab, Bortezomib, Lenalidomide, and Dexamethasone (Isa-VRd) in Patients with Newly Diagnosed Multiple Myeloma (NDMM) Not Eligible or with No Immediate Intent for Transplant: Long-Term Efficacy and Safety in a Phase 1b Study

Enrique M Ocio, Aurore Perrot, Pierre Bories, Jesús F. San-Miguel, Lionel Karlin, Joaquin Martinez-Lopez, Song-Yau Wang, Sara Bringhen, Maria-Victoria Mateos, Paula Rodríguez-Otero, Stefania Oliva, Axel Nogai, Bruno Paiva, Yi Li, Eric Le Bras, Sandrine Macé, Ercem Kodas, Helgi Van de Velde, Philippe Moreau
Journal: Blood
Blood (2024) 144 (Supplement 1): 1976.
https://doi.org/10.1182/blood-2024-200135
Published: 2024
Journal Articles

Clinical Value of Peripheral Residual Disease (PRD) and Measurable Residual Disease (MRD) in Newly Diagnosed Elderly Patients in the GEM2017FIT Trial

Noemi Puig, Bruno Paiva, María T Cedena, Cristina Agullo, Teresa Contreras, Sergio Castro, Ana Maria Sureda Balari, Veronica Gonzalez-Calle, Albert Oriol, Enrique M Ocio, Laura Rosiñol Dachs, Yolanda González-Montes, Joan Bargay, Esther González García, Miguel Teodoro Hernández Garcia, Angel Ramirez, Alexia Suarez-Cabrera, María-Jesús Blanchard, Sebastián Garzón, Luis Felipe Casado Montero, Valentin Cabanas Perianes, Jaime Perez de Oteyza, Mercedes Gironella, Joaquín Martínez-Lopez, Pilar Delgado, Elena Prieto, Juan-Jose Lahuerta Palacios, Joan Bladé, Jesús F. San-Miguel, Maria- Victoria Mateos
Journal: Blood
Blood (2024) 144 (Supplement 1): 365.
https://doi.org/10.1182/blood-2024-209748
Published: 2024
Journal Articles

Improved Risk Stratification of Smoldering Multiple Myeloma (SMM) Using Trajectory Data in the Pangea 2.0 Model: A Multicenter Study in 1,431 Participants

Floris Chabrun, Daniel Schwartz, Susanna Gentile, Tulika R Gupta, Noelia Collado Gisbert, Esperanza Martín-Sánchez, Rosalinda Termini, Jacqueline F Perry, Annie Cowan, Federico Ferrari, Samuel Freeman, Robert A. Redd, Vidhi Patel, Patrick Costello, Catherine Tobia, Romanos Sklavenitis-Pistofidis, Habib El-Khoury, Michael Timonian, David J Lee, Elizabeth D. Lightbody, Hadley Barr, Priya Kaur, Katelyn Downey, Sally Phan, Maya Patel, Jennifer Lamb, Nana Ama Boadi-Acheampong, Foteini Theodorakakou, Despina Fotiou, Christine-Ivy Liacos, Selina J Chavda, Louise Ainley, Elizabeth K. O'Donnell, Catherine R. Marinac, Gad Getz, Omar Nadeem, Kwee Yong, Efstathios Kastritis, Meletios Dimopoulos, Jesús F. San-Miguel, Bruno Paiva, Lorenzo Trippa, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 1017.
https://doi.org/10.1182/blood-2024-205705
Published: 2024
Journal Articles

Unraveling Long-Term Survival of Multiple Myeloma Patients, the GEM2000 Experience

Rafael Alonso Fernandez, Andrés Arroyo Barea, Maria Teresa Cedena Romero, Laura Rosiñol Dachs, Javier de la Rubia, Sara Miqueleiz, Veronica Gonzalez-Calle, Felipe De Arriba, Luis Felipe Casado Montero, Miguel Teodoro Hernandez, Maria Mas Esteve, Pascual Fernandez, Paula Rodríguez-Otero, Carmen Calle Primo, Eugenia Abella, Paz Ribas, Adrian Alegre, Juan Miguel Bergua, Irene Gomez-Catalan, Jose Maria Arguiñano Perez, Luis Palomera, Enrique M Ocio, Maria Jose Busto Medina, Nieves Somolinos, Jose Maria Alonso Alonso, Aránzazu García Mateo, Joan Bargay, Pilar Delgado, Dunia De Miguel Llorente, Javier de la Cruz, Maria Victoria Mateos, Jesús F. San-Miguel, Joan Bladé, Juan-Jose Lahuerta Palacios, Joaquin Martinez Lopez
Journal: Blood
Blood (2024) 144 (Supplement 1): 1957.
https://doi.org/10.1182/blood-2024-211383
Published: 2024
Journal Articles

First-in-Human Phase 1 Study of SAR442257 in Patients with Relapsed/Refractory Multiple Myeloma and Non-Hodgkin Lymphoma

Fredrik Schjesvold, Tomas Jelinek, Kamila Polgarova, Ludek Pour, Sung-Soo Yoon, Won Seog Kim, Alexander Fosså, Jesús F. San-Miguel, Miguel Canales, Paula Rodríguez-Otero, Albert Oriol, Javier de la Rubia, Joaquín Martínez-Lopez, Sonia González De Villambrosia, Prashant Kapoor, Ola Landgren, James Edward Hoffman, Noopur Raje, Hongfang Wang, Kunal Jhunjhunwala, Liang Zhao, Zhini Wang, Mony Morisse, Helgi Van de Velde, Nitya Nathwani
Journal: Blood
Blood (2024) 144 (Supplement 1): 1992.
https://doi.org/10.1182/blood-2024-204614
Published: 2024