RT Journal Article
A1 Nieswandt, Bernhard
A1 Heemskerk, Johan W. M.
T1 Dividing VI by X(a)
JF Blood
JO Blood
YR 2011
DO 10.1182/blood-2011-02-332742
VO 117
IS 14
SP 3704
OP 3705
SN 0006-4971
AB In this issue of Blood, Al-Tamimi and colleagues demonstrate that activated coagulation factor X (FXa) efficiently triggers the down-regulation of the platelet-activating collagen receptor glycoprotein VI (GPVI), thereby providing a novel negative feedback mechanism in the thrombotic cascade.1Vascular injury triggers adhesion and aggregation of platelets (primary hemostasis) and coagulation-dependent fibrin formation (secondary hemostasis). These processes are essential for hemostasis but may also lead to occlusion of diseased vessels by thrombus formation and potentially fatal embolization. Therefore, coagulation as well as platelet inhibitors are routinely used in the clinic to treat or prevent thrombotic disease states such as myocardial infarction or stroke.
RD 11/15/2025
UL https://doi.org/10.1182/blood-2011-02-332742