@article{10.1182/blood.V73.3.662.662,
    author = {Barbano, G and Saleh, MN and Mori, PG and LoBuglio, AF and Shaw, DR},
    title = {Effect of intravenous gammaglobulin on circulating and platelet-bound antibody in immune thrombocytopenia},
    journal = {Blood},
    volume = {73},
    number = {3},
    pages = {662-665},
    year = {1989},
    month = {02},
    abstract = {Ten patients with idiopathic thrombocytopenic purpura (ITP) were studied before and following a rise in circulating platelets subsequent to infusions of intravenous gammaglobulin (400 mg/kg/day x 5 days). We quantitated the amount of circulating IgG capable of binding to normal donor platelets in vitro using an 125I-monoclonal anti-human IgG assay, as well as the amount of IgG associated with the patients' platelets before and following therapy. We found no evidence for a decrease in platelet-specific IgG antibodies in these patients undergoing an acute response to therapy. These data suggest that the short-term efficacy of intravenous gammaglobulin is due to effects other than a substantive reduction in platelet reactive antibodies, such as the alteration of IgG-coated platelet destruction.},
    issn = {0006-4971},
    doi = {10.1182/blood.V73.3.662.662},
    url = {https://doi.org/10.1182/blood.V73.3.662.662},
    eprint = {https://ashpublications.org/blood/article-pdf/73/3/662/599313/662.pdf},
}